Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 41433..41959 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP091493 | ||
| Organism | Enterobacter cloacae complex sp. ECL405 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | L3070_RS23715 | Protein ID | WP_000323025.1 |
| Coordinates | 41433..41720 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | L3070_RS23720 | Protein ID | WP_000534858.1 |
| Coordinates | 41720..41959 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L3070_RS23680 (L3070_23680) | 37003..37179 | - | 177 | WP_001371930.1 | hypothetical protein | - |
| L3070_RS23685 (L3070_23685) | 37690..38634 | + | 945 | WP_000778029.1 | DUF5417 domain-containing protein | - |
| L3070_RS23690 (L3070_23690) | 38730..39332 | + | 603 | WP_012695474.1 | hypothetical protein | - |
| L3070_RS23695 (L3070_23695) | 39392..39742 | + | 351 | WP_000743059.1 | hypothetical protein | - |
| L3070_RS23700 (L3070_23700) | 39789..39992 | + | 204 | WP_001015183.1 | hypothetical protein | - |
| L3070_RS23705 (L3070_23705) | 40274..40594 | + | 321 | WP_000332796.1 | hypothetical protein | - |
| L3070_RS23710 (L3070_23710) | 41207..41332 | - | 126 | WP_229020258.1 | DUF5431 family protein | - |
| L3070_RS23715 (L3070_23715) | 41433..41720 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| L3070_RS23720 (L3070_23720) | 41720..41959 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| L3070_RS23725 (L3070_23725) | 41984..42088 | + | 105 | Protein_48 | hypothetical protein | - |
| L3070_RS23730 (L3070_23730) | 42222..43145 | - | 924 | WP_000167917.1 | cation diffusion facilitator family transporter | - |
| L3070_RS23735 (L3070_23735) | 43345..43917 | - | 573 | WP_001515348.1 | cytochrome b/b6 domain-containing protein | - |
| L3070_RS23740 (L3070_23740) | 44393..45631 | - | 1239 | WP_000219087.1 | IS110-like element ISEsa2 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaSHV-12 / mph(A) / blaTEM-1B / dfrA19 / blaIMP-26 / qacE / sul1 / mcr-9 | - | 1..362923 | 362923 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T233431 WP_000323025.1 NZ_CP091493:c41720-41433 [Enterobacter cloacae complex sp. ECL405]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T233431 NZ_HG938355:535978-536298 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
ATGCGCAGGGGCGATCTTGTGACGGTTGCTCTGGCTGGTGATTTCGGAAAACCGCGCCCCGCCCTTGTGATCCAATCCGA
CCTTTTCGACACCGACACGCTAACGGTTCTGCTGCTGTCCAGTACCATTGTTAATACGCCGCTCATCCGCATCATGGTCC
AGCCCACGCCCAGGAACGCGCTCAACAGCCCCTCCCAGATCATGATCGACAAGGCGATGACCCTCAAGCGGGAAAAGATA
GGGAGGGTTTTCGGCTCGATCGAAGATGACATTCTCGTAGCCGTGAATCGGTCGCTTGCCGTGTTCTTTGGCTTGGCCTG
A
ATGCGCAGGGGCGATCTTGTGACGGTTGCTCTGGCTGGTGATTTCGGAAAACCGCGCCCCGCCCTTGTGATCCAATCCGA
CCTTTTCGACACCGACACGCTAACGGTTCTGCTGCTGTCCAGTACCATTGTTAATACGCCGCTCATCCGCATCATGGTCC
AGCCCACGCCCAGGAACGCGCTCAACAGCCCCTCCCAGATCATGATCGACAAGGCGATGACCCTCAAGCGGGAAAAGATA
GGGAGGGTTTTCGGCTCGATCGAAGATGACATTCTCGTAGCCGTGAATCGGTCGCTTGCCGTGTTCTTTGGCTTGGCCTG
A
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT233431 WP_000534858.1 NZ_CP091493:c41959-41720 [Enterobacter cloacae complex sp. ECL405]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT233431 NZ_HG938355:535763-535978 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
ATGGCCAGTTCCGTGAATGAGCGTGTCAGAAAACGTCGTGAAAATCTCCGGGCGTCCGGGTTGCGTCCAGTGCAAATTTG
GGTTCCCGATACGCGGCGCCCTGGTTTTGCAGAGGAATGCCATCGGCAGTCGCGTTTGGTCGCGGCGGCGGATGCAGCAG
ATCCCGATCTTATGAAATTTCTGGATGATGCCCTGGCTGATCTCGGGGAGCAATGA
ATGGCCAGTTCCGTGAATGAGCGTGTCAGAAAACGTCGTGAAAATCTCCGGGCGTCCGGGTTGCGTCCAGTGCAAATTTG
GGTTCCCGATACGCGGCGCCCTGGTTTTGCAGAGGAATGCCATCGGCAGTCGCGTTTGGTCGCGGCGGCGGATGCAGCAG
ATCCCGATCTTATGAAATTTCTGGATGATGCCCTGGCTGATCTCGGGGAGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|