233430

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 4817278..4817894 Replicon chromosome
Accession NZ_CP091492
Organism Enterobacter cloacae complex sp. ECL405

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L3070_RS23110 Protein ID WP_094935277.1
Coordinates 4817278..4817649 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L3070_RS23115 Protein ID WP_094935276.1
Coordinates 4817652..4817894 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3070_RS23095 (L3070_23095) 4814778..4815680 + 903 WP_010436855.1 formate dehydrogenase subunit beta -
L3070_RS23100 (L3070_23100) 4815677..4816312 + 636 WP_010436852.1 formate dehydrogenase cytochrome b556 subunit -
L3070_RS23105 (L3070_23105) 4816309..4817238 + 930 WP_023309751.1 formate dehydrogenase accessory protein FdhE -
L3070_RS23110 (L3070_23110) 4817278..4817649 - 372 WP_094935277.1 type II toxin-antitoxin system VapC family toxin Toxin
L3070_RS23115 (L3070_23115) 4817652..4817894 - 243 WP_094935276.1 CopG family transcriptional regulator Antitoxin
L3070_RS23120 (L3070_23120) 4818094..4819014 + 921 WP_094935275.1 alpha/beta hydrolase -
L3070_RS23125 (L3070_23125) 4819023..4819964 - 942 WP_039264191.1 fatty acid biosynthesis protein FabY -
L3070_RS23130 (L3070_23130) 4820009..4820446 - 438 WP_008501836.1 D-aminoacyl-tRNA deacylase -
L3070_RS23135 (L3070_23135) 4820443..4821324 - 882 WP_126802424.1 virulence factor BrkB family protein -
L3070_RS23140 (L3070_23140) 4821318..4821917 - 600 WP_094935274.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-109)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13680.87 Da        Isoelectric Point: 7.3604

>T233430 WP_094935277.1 NZ_CP091492:c4817649-4817278 [Enterobacter cloacae complex sp. ECL405]
MERMAVFDTNILIDLFNNRVEAADAIDRTASHRAISLITWMEVMVGARKHGHEAKTATVMGVFEIIDITRDIAERSVILR
EKHGMKLPDAIILATAQSRSCPLISRNTKDFSGITGVVSPYQL

Download         Length: 372 bp

>T233430 NZ_HG938354:c1558571-1558278 [Neorhizobium galegae bv. orientalis str. HAMBI 540]
ATGCGTTTTAGCTTTTCTGTCGAAGCGGAAGAGGACATCATTGCAATCGCCGAGCAAAGTGTCCGCATGTTCGGATCCGC
ACAGGCTAGGCGGTATTATGACGAGCTTTTTGCGGTGCTTGACCTGATTGCTGCGAATCCGCGAATGGCGCGTGAGCGAG
AAGAGATTTCGCCGCCCGTTAGGATCCATCCGTTCAAAGCGCATCTCGTTGTGTACCGGATCGAAGAGAATGGAGCTATT
TTCGTGATCCGAATACGCCATGGACACGAAGACTGGGCCGGCGATCCTGTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9455.65 Da        Isoelectric Point: 4.2803

>AT233430 WP_094935276.1 NZ_CP091492:c4817894-4817652 [Enterobacter cloacae complex sp. ECL405]
MILSADLDMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT233430 NZ_HG938354:c1558825-1558571 [Neorhizobium galegae bv. orientalis str. HAMBI 540]
ATGGCTACTATGAACGTATCTTTACCAGACCCAATGAAAGATTGGGTTGAGGCGCAAGCGAGGACCGGGCGATATTCCAA
TGCCAGTGACTATGTGCGCGACCTGATTCGGAGAGACCAAGCGCGCAGTGATAAGATTGCTGCCATGCAGCGCTTTGTCG
ACGACGGTCTCAAAAGTGGTGTTGGCGGCCGCTCAAAGGACGAACTCTTTGCCGCGGCTGTCGTGCGCGCGGAAACCACC
CGCGGCAGCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References