Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4161422..4162175 Replicon chromosome
Accession NZ_CP091492
Organism Enterobacter cloacae complex sp. ECL405

Toxin (Protein)


Gene name yeeV Uniprot ID A0A097QYR4
Locus tag L3070_RS19925 Protein ID WP_025799003.1
Coordinates 4161422..4161799 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7T0E0C6
Locus tag L3070_RS19930 Protein ID WP_072269511.1
Coordinates 4161849..4162175 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3070_RS19895 (L3070_19895) 4157004..4158851 + 1848 WP_023309228.1 RNA polymerase sigma factor RpoD -
L3070_RS19900 (L3070_19900) 4158965..4159471 - 507 WP_029741755.1 G/U mismatch-specific DNA glycosylase -
L3070_RS19910 (L3070_19910) 4159775..4160620 - 846 WP_025799009.1 DUF4942 domain-containing protein -
L3070_RS19915 (L3070_19915) 4160702..4160905 - 204 WP_025799007.1 DUF957 domain-containing protein -
L3070_RS19920 (L3070_19920) 4160934..4161425 - 492 WP_045888216.1 DUF5983 family protein -
L3070_RS19925 (L3070_19925) 4161422..4161799 - 378 WP_025799003.1 TA system toxin CbtA family protein Toxin
L3070_RS19930 (L3070_19930) 4161849..4162175 - 327 WP_072269511.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L3070_RS19935 (L3070_19935) 4162232..4162453 - 222 WP_045888217.1 DUF987 domain-containing protein -
L3070_RS19940 (L3070_19940) 4162467..4162946 - 480 WP_025798999.1 DNA repair protein RadC -
L3070_RS19945 (L3070_19945) 4162958..4163389 - 432 WP_088903392.1 antirestriction protein -
L3070_RS19950 (L3070_19950) 4163612..4166764 - 3153 WP_045888218.1 autotransporter domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13993.97 Da        Isoelectric Point: 6.8515

>T233429 WP_025799003.1 NZ_CP091492:c4161799-4161422 [Enterobacter cloacae complex sp. ECL405]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR

Download         Length: 378 bp

>T233429 NZ_HG938354:1378655-1379059 [Neorhizobium galegae bv. orientalis str. HAMBI 540]
TTGACCGGGTATTTGCTCGATACGAACATCATCAGCGACATCATACGCAATCCGTTCGGATCGGCTGCGCGTCGCGTCGA
AGAGATTGACCCCAAGGAGATCTGCACCAGTATCGTCGTCGCTGCTGAACTGCGATACGGCTGCGCGAAAAAAGGCTCAA
CCAAGCTATTGGCGAAAGTCGAAAGCATTCTTGAAACGATACCGATCATGCCCCTGGATATGCCCGCCGACATCAACTAC
GGAGGCATCCGTGCGAAACTGGAAGCTGCGGGAGAAACTATCGGCCTCAACGATATGCTGATCGCCGCGCATGCTTGCGC
GTTGAACCTGACGCTCGTGACGGACAACACCCGTGAGTTCCAGCGCATTCGTGGTCTCGATCTGGAAAACTGGCTTGAGC
GATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12016.71 Da        Isoelectric Point: 6.4674

>AT233429 WP_072269511.1 NZ_CP091492:c4162175-4161849 [Enterobacter cloacae complex sp. ECL405]
IAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELNPRHQHGVTLYA
KGLTCNADTLGSCGYVYIAIYPTPATTE

Download         Length: 327 bp

>AT233429 NZ_HG938354:1378386-1378658 [Neorhizobium galegae bv. orientalis str. HAMBI 540]
GTGCCTATTCCATTGCCTTCATCCCGGCCGAAAGAAGTGAAGCTGTTCCGCAACAATCGCAGTCAAGCTGTGCGCATTCC
AGCGGAGTTCGAGTTGCCGGGGGACCGCGTCTTGATTCATCGTGAAGGAAACAAGCTCATCATTGAGCCTATAGCCAGGC
CAGCCAACATCATTGAGCTTCTTGCCGAATGGAAGAAGGAGGATCTTCTCGGACCTGAAGACCAGTTCCCGGATATCGAG
GATATGCCTGCCAAACCGGAGAACATTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QYR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T0E0C6

References