Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3876874..3877531 Replicon chromosome
Accession NZ_CP091492
Organism Enterobacter cloacae complex sp. ECL405

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag L3070_RS18520 Protein ID WP_021242050.1
Coordinates 3876874..3877284 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag L3070_RS18525 Protein ID WP_010435322.1
Coordinates 3877265..3877531 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3070_RS18500 (L3070_18500) 3872867..3874600 - 1734 WP_039262981.1 single-stranded-DNA-specific exonuclease RecJ -
L3070_RS18505 (L3070_18505) 3874606..3875319 - 714 WP_023309097.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L3070_RS18510 (L3070_18510) 3875348..3876244 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
L3070_RS18515 (L3070_18515) 3876346..3876867 + 522 WP_064673272.1 flavodoxin FldB -
L3070_RS18520 (L3070_18520) 3876874..3877284 - 411 WP_021242050.1 protein YgfX Toxin
L3070_RS18525 (L3070_18525) 3877265..3877531 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
L3070_RS18530 (L3070_18530) 3877826..3878806 + 981 WP_029739202.1 tRNA-modifying protein YgfZ -
L3070_RS18535 (L3070_18535) 3878881..3879540 - 660 WP_033146591.1 hemolysin III family protein -
L3070_RS18540 (L3070_18540) 3879706..3880017 - 312 WP_047060448.1 N(4)-acetylcytidine aminohydrolase -
L3070_RS18545 (L3070_18545) 3880069..3880800 + 732 WP_029739204.1 MurR/RpiR family transcriptional regulator -
L3070_RS18550 (L3070_18550) 3880917..3882350 + 1434 WP_033146593.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T233427 WP_021242050.1 NZ_CP091492:c3877284-3876874 [Enterobacter cloacae complex sp. ECL405]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T233427 NZ_HG938354:c253736-253314 [Neorhizobium galegae bv. orientalis str. HAMBI 540]
GTGAGACTGCTCATCGACACCAACGTTCTGCCCGAAGTAACAAAGCCCCGTCCCGACGCACGCGTTTTGGAATGGCTTGG
CGGGCTCGACGAAGACCGCGCCTATATCAGCGTCATATCAATCGCAGAAATCCGCCGAGGCGTCGCTTTGATGGATAGTG
GGCAAAAACGCGACACTCTGGCGGAATGGCTTTCGCATGACCTGCCGCAACGTTTCGAGGGGCGGGTGATTCCGGTGGAA
GAGCCTGTCGCCCTGTCGTGGGGCGATCTCATGGCACTTGCCAAGCAGAGTGGTCGCGGACTGGCTTCAATGGACGGATT
AATCGCCGCCACTGCGATAGCACACCATCTCACCCTCGCGACGCGCAACACCAAAGATTTTGAAGGTTTCGGGATTGATA
TGATCAATCCGTGGAACGGCTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT233427 WP_010435322.1 NZ_CP091492:c3877531-3877265 [Enterobacter cloacae complex sp. ECL405]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233427 NZ_HG938354:c253999-253733 [Neorhizobium galegae bv. orientalis str. HAMBI 540]
ATGCGGCCATCAGCACACGATGATAGGATCTGGACGGTCGCCGGCGCCAAAGCAAAACTCTCCGAGGTCATCGAGCGAGC
ACAATCAGTGCCCCAGACAATCACACGGAACGGAAAACCAAGCGTGGTTGTCGTTTCGGCGGAAGAATGGCAGCGGAAAA
CAGCACGCAAAGGATCACTTGCGGAATTCCTCATGGACTCGCCGCTCCGCGGCGCCGGCTTGGATCTGGATCGTGAACGC
GATGAGCCACGCGATCTGCCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References