23342

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3098491..3099145 Replicon chromosome
Accession NC_011741
Organism Escherichia coli IAI1

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag ECIAI1_RS15090 Protein ID WP_000244777.1
Coordinates 3098491..3098898 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag ECIAI1_RS15095 Protein ID WP_000354046.1
Coordinates 3098879..3099145 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECIAI1_RS15070 3094448..3096181 - 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -
ECIAI1_RS15075 3096187..3096897 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ECIAI1_RS15080 3096922..3097818 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
ECIAI1_RS15085 3097930..3098451 + 522 WP_001055870.1 flavodoxin FldB -
ECIAI1_RS15090 3098491..3098898 - 408 WP_000244777.1 toxin CptA Toxin
ECIAI1_RS15095 3098879..3099145 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
ECIAI1_RS15100 3099388..3100368 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
ECIAI1_RS15105 3100564..3101223 - 660 WP_000250274.1 hemolysin III family protein -
ECIAI1_RS15110 3101387..3101698 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
ECIAI1_RS15115 3101743..3103176 + 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
ECIAI1_RS15120 3103233..3103976 - 744 WP_000951948.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T23342 WP_000244777.1 NC_011741:c3098898-3098491 [Escherichia coli IAI1]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T23342 NC_011741:c3098898-3098491 [Escherichia coli IAI1]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT23342 WP_000354046.1 NC_011741:c3099145-3098879 [Escherichia coli IAI1]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT23342 NC_011741:c3099145-3098879 [Escherichia coli IAI1]
ATGGACATTAATAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References