Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4659923..4660539 Replicon chromosome
Accession NZ_CP091486
Organism Enterobacter cloacae complex sp. ECL411

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L3069_RS22310 Protein ID WP_080298797.1
Coordinates 4659923..4660294 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag L3069_RS22315 Protein ID WP_023298920.1
Coordinates 4660297..4660539 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3069_RS22295 (L3069_22295) 4657423..4658325 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
L3069_RS22300 (L3069_22300) 4658322..4658957 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
L3069_RS22305 (L3069_22305) 4658954..4659883 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
L3069_RS22310 (L3069_22310) 4659923..4660294 - 372 WP_080298797.1 type II toxin-antitoxin system VapC family toxin Toxin
L3069_RS22315 (L3069_22315) 4660297..4660539 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
L3069_RS22320 (L3069_22320) 4660739..4661659 + 921 WP_038416944.1 alpha/beta hydrolase -
L3069_RS22325 (L3069_22325) 4661668..4662609 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
L3069_RS22330 (L3069_22330) 4662654..4663091 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
L3069_RS22335 (L3069_22335) 4663088..4663969 - 882 WP_023298923.1 virulence factor BrkB family protein -
L3069_RS22340 (L3069_22340) 4663963..4664562 - 600 WP_023315056.1 glucose-1-phosphatase -
L3069_RS22345 (L3069_22345) 4664681..4665481 - 801 WP_038416949.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13612.66 Da        Isoelectric Point: 6.4865

>T233406 WP_080298797.1 NZ_CP091486:c4660294-4659923 [Enterobacter cloacae complex sp. ECL411]
MEHMAVYDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T233406 NZ_HG916826:1211383-1212135 [Pseudomonas pseudoalcaligenes CECT 5344]
ATGGATATCTGGCAACTATGCGACGGCGAGCGACAGGTGCGACCGCTGCGCGGCAAGCTGTTGCGCATGGTGGAGAGCCA
GGCCCAGGTTGCGACCCTGCAACTGGTGGATAACCTGGCCGAGCAGACCCTGCTCGAGGAACTGCTCGAGAGCAGCAAGC
CGCCGCTGCCTGAAGCCGCCGAGCCGTTGCACTACCTGCTGAAGACGCCCTTTCGTTATCCGCCGCTGCGTTGGGGCTCG
CGCTTCGGCCGCGTGCACGAACCCAGCCTGTTCTACGCCGCTCAGCGTCTGCAAACGGCGATGGCCGAGGCCGCCTACTA
CCGTTTCGTATTGTGGAATGGCATGGTCGTGCCGCCGCCCAGTGGCCGCATCCTCTCCGAGCATTCGACCTTCGAGGCGC
GTTACCGCGTCGAGCACGGTATCCAGTTGCAACAGTCGCCTTTCGCTCAACATGACGCACTGTTGGCTCACCCCAGTGAT
TACAGCGTGCCTCAGCGTCTCGGTACGTCGATGCGCGCGGCGGGCATTCAGGCTTTCGAGTACCGCTCGGCACGCTGTCC
TGACGGTGGCAGCAATGTGGCGCTCTACGTGCCGGCTGCGTTCGTGGAGAAGCGTCCGCGTAATCTGACGGCCTGGTTGT
GTGAAACCACGAGCGAGTACGTGGCGTTCAAGCATGCGCAAACGCCGGATCAACCACGGCTGTTTCACTGGGAGCAGTTT
CTGGTGCAGGGGCAATTGCCGCACCCCGCGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT233406 WP_023298920.1 NZ_CP091486:c4660539-4660297 [Enterobacter cloacae complex sp. ECL411]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT233406 NZ_HG916826:1210928-1211299 [Pseudomonas pseudoalcaligenes CECT 5344]
ATGAGTGCTGTGACTCGCTCTCAGCCCGATGCCGATGCGGTACTGGCTAAAGCCCTGCTCAATACCCGTGAGCAACTGGG
GCTGACGCAGCAGGAGCTGGCCGACATCGTTGGCGTCCATCGCAGTGCCATCAGCCGCTGGAGTGAGCAGGGTGGTTTGC
GTCCGCAGAGCAAGACCGGCGAGCTGGCGCTGTTGCTGATACGCGCCTATCGCGCGCTGTTTGCCCTGTTTGGCGGCAAT
CAGCAGGACATGCGCCATTTTCTGCGCACCGAAAATCGCCATCTGGCAGGTATTCCGCTGCAGCAGATGAGTCAGGTGCA
GGGGCTGGTGCGTGTTGTCGAGTATCTGGACGCCATTCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References