Detailed information of TA system TA233405

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3836264..3836921
• Replicon: chromosome
• Accession: NZ_CP091486
• Organism: Enterobacter cloacae complex sp. ECL411

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L3069_RS18375
• Protein ID: WP_038416677.1
• Coordinates: 3836264..3836674 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: G8LDB7
• Locus tag: L3069_RS18380
• Protein ID: WP_003863437.1
• Coordinates: 3836655..3836921 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L3069_RS18355 (L3069_18355)	3832262..3833995	-	1734	WP_038416675.1	single-stranded-DNA-specific exonuclease RecJ	-
L3069_RS18360 (L3069_18360)	3834001..3834714	-	714	WP_022649304.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
L3069_RS18365 (L3069_18365)	3834743..3835639	-	897	WP_003863442.1	site-specific tyrosine recombinase XerD	-
L3069_RS18370 (L3069_18370)	3835741..3836262	+	522	WP_023306886.1	flavodoxin FldB	-
L3069_RS18375 (L3069_18375)	3836264..3836674	-	411	WP_038416677.1	protein YgfX	Toxin
L3069_RS18380 (L3069_18380)	3836655..3836921	-	267	WP_003863437.1	FAD assembly factor SdhE	Antitoxin
L3069_RS18385 (L3069_18385)	3837216..3838196	+	981	WP_038416679.1	tRNA-modifying protein YgfZ	-
L3069_RS18390 (L3069_18390)	3838282..3838941	-	660	WP_022649307.1	hemolysin III family protein	-
L3069_RS18395 (L3069_18395)	3839208..3839939	+	732	WP_022649308.1	MurR/RpiR family transcriptional regulator	-
L3069_RS18400 (L3069_18400)	3840056..3841489	+	1434	WP_038416681.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16337.20 Da
• Isoelectric Point: 11.4775

>T233405 WP_038416677.1 NZ_CP091486:c3836674-3836264 [Enterobacter cloacae complex sp. ECL411]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINSRQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T233405 NZ_HG916826:836341-836766 [Pseudomonas pseudoalcaligenes CECT 5344]
ATGTTCGTCCTCGACACTAATGTCGTGTCCGAACTGCGCAAGGCCAAGAGTGCCAAGGCCGACCCGCGCCTAGTGGCCTG
GGCTCAGCGCCTGCTGCCGGGGCAGTTGTTCATTTCCGCGATCACCGTGCTGGAGCTGGAAACCGGCGTGCTGCTAGTGG
AACGACGCGACCCGCAGCAGGGCCGCCTGCTGCGCTCCTGGCTCGATAGCCATGTACTACCCGGCTTCGCCGGACGCATC
CTGCCGGTCGACGCCGCCGTGGCGCAGCGTTGCGCGCAATTGCATGTCCCCGACCCACGCGCCGAACGCGATGCCTTGAT
CGTGGCCACGGCATTGGTGCATGGCATGACGGTCGCCACACGCAACGTGGCGGACTTTCTGCCCACAGGCGTGGCACTGA
TCAACCCTTGGGAGTTTGCTGGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10526.96 Da
• Isoelectric Point: 4.8310

>AT233405 WP_003863437.1 NZ_CP091486:c3836921-3836655 [Enterobacter cloacae complex sp. ECL411]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT233405 NZ_HG916826:836090-836341 [Pseudomonas pseudoalcaligenes CECT 5344]
ATGCAAACCATCCTTACCAGTCGCGAGTTCAATCAGGACGCCAGTGGTGCCAAGCGTGCTGCCAAACATGGGCCGGTCTT
TATCACGGATCGTGGCAAACCGGCTCATGTGCTGCTGAGCATCGAGGAATACCAGCGTCTGACCGGCGGCCCCGGCAGCA
TCATCGATCTGCTGGCCATGCCGACAGTCGAGGACATCGAGTTCGAGGCGCCGCGTGCGCAAGGTTTGTCGCGCCCGGCG
GATTTGAGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A837F8P5