Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3884986..3885643 Replicon chromosome
Accession NZ_CP091481
Organism Enterobacter cloacae complex sp. ECL414

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag L3068_RS18670 Protein ID WP_014885136.1
Coordinates 3884986..3885396 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag L3068_RS18675 Protein ID WP_010435322.1
Coordinates 3885377..3885643 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3068_RS18650 (L3068_18650) 3880980..3882713 - 1734 WP_023331239.1 single-stranded-DNA-specific exonuclease RecJ -
L3068_RS18655 (L3068_18655) 3882719..3883432 - 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L3068_RS18660 (L3068_18660) 3883461..3884357 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
L3068_RS18665 (L3068_18665) 3884459..3884980 + 522 WP_014885135.1 flavodoxin FldB -
L3068_RS18670 (L3068_18670) 3884986..3885396 - 411 WP_014885136.1 protein YgfX Toxin
L3068_RS18675 (L3068_18675) 3885377..3885643 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
L3068_RS18680 (L3068_18680) 3885938..3886918 + 981 WP_088127263.1 tRNA-modifying protein YgfZ -
L3068_RS18685 (L3068_18685) 3887003..3887662 - 660 WP_023331242.1 hemolysin III family protein -
L3068_RS18690 (L3068_18690) 3887928..3888659 + 732 WP_014885139.1 MurR/RpiR family transcriptional regulator -
L3068_RS18695 (L3068_18695) 3888776..3890209 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T233390 WP_014885136.1 NZ_CP091481:c3885396-3884986 [Enterobacter cloacae complex sp. ECL414]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T233390 NZ_HG813242:c1727951-1727589 [Staphylococcus epidermidis PM221]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT233390 WP_010435322.1 NZ_CP091481:c3885643-3885377 [Enterobacter cloacae complex sp. ECL414]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233390 NZ_HG813242:c1728118-1727948 [Staphylococcus epidermidis PM221]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References