Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yafW-ykfI/CbtA-CbeA |
| Location | 917315..917994 | Replicon | chromosome |
| Accession | NZ_CP091481 | ||
| Organism | Enterobacter cloacae complex sp. ECL414 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | S1FHS4 |
| Locus tag | L3068_RS04275 | Protein ID | WP_000854680.1 |
| Coordinates | 917315..917656 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | S1EWR7 |
| Locus tag | L3068_RS04280 | Protein ID | WP_000070396.1 |
| Coordinates | 917677..917994 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L3068_RS04250 (L3068_04250) | 912505..912906 | + | 402 | WP_117582231.1 | sigma factor-binding protein Crl | - |
| L3068_RS04255 (L3068_04255) | 913020..914072 | - | 1053 | WP_014882683.1 | phosphoporin PhoE | - |
| L3068_RS04260 (L3068_04260) | 914378..915481 | + | 1104 | WP_014882684.1 | glutamate 5-kinase | - |
| L3068_RS04265 (L3068_04265) | 915493..916746 | + | 1254 | WP_117582234.1 | glutamate-5-semialdehyde dehydrogenase | - |
| L3068_RS04275 (L3068_04275) | 917315..917656 | - | 342 | WP_000854680.1 | type IV toxin-antitoxin system toxin YkfI | Toxin |
| L3068_RS04280 (L3068_04280) | 917677..917994 | - | 318 | WP_000070396.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| L3068_RS04285 (L3068_04285) | 918013..918234 | - | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| L3068_RS04290 (L3068_04290) | 918243..918719 | - | 477 | WP_000811693.1 | RadC family protein | - |
| L3068_RS04295 (L3068_04295) | 918735..919193 | - | 459 | WP_205920785.1 | antirestriction protein | - |
| L3068_RS04300 (L3068_04300) | 919291..919530 | - | 240 | WP_180208556.1 | DUF905 domain-containing protein | - |
| L3068_RS04305 (L3068_04305) | 919607..920074 | - | 468 | WP_001547765.1 | protein YkfB | - |
| L3068_RS04310 (L3068_04310) | 920097..920540 | - | 444 | WP_001547764.1 | lipoprotein YafY | - |
| L3068_RS04315 (L3068_04315) | 920540..920776 | - | 237 | WP_001144031.1 | protein YpjK | - |
| L3068_RS04320 (L3068_04320) | 920817..921518 | - | 702 | WP_117582372.1 | WYL domain-containing protein | - |
| L3068_RS04325 (L3068_04325) | 921735..922556 | - | 822 | WP_000197389.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12892.95 Da Isoelectric Point: 9.6543
>T233378 WP_000854680.1 NZ_CP091481:c917656-917315 [Enterobacter cloacae complex sp. ECL414]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
Download Length: 342 bp
>T233378 NZ_HG813240:c3065517-3065122 [Mycobacterium tuberculosis 49-02]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11982.62 Da Isoelectric Point: 7.0270
>AT233378 WP_000070396.1 NZ_CP091481:c917994-917677 [Enterobacter cloacae complex sp. ECL414]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT233378 NZ_HG813240:c3065096-3064830 [Mycobacterium tuberculosis 49-02]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|