Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2411237..2412215 | Replicon | chromosome |
| Accession | NZ_CP091476 | ||
| Organism | Bacillus cereus strain GSICC 30237 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | L2I54_RS12470 | Protein ID | WP_000624975.1 |
| Coordinates | 2411237..2411974 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | M1PKC2 |
| Locus tag | L2I54_RS12475 | Protein ID | WP_000237819.1 |
| Coordinates | 2412087..2412215 (+) | Length | 43 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L2I54_RS12440 (L2I54_12405) | 2406368..2407078 | + | 711 | WP_000787499.1 | class I SAM-dependent methyltransferase | - |
| L2I54_RS12445 (L2I54_12410) | 2407196..2407603 | + | 408 | WP_000063589.1 | VOC family protein | - |
| L2I54_RS12450 (L2I54_12415) | 2407937..2408719 | + | 783 | WP_000381791.1 | class I SAM-dependent methyltransferase | - |
| L2I54_RS12455 (L2I54_12420) | 2408877..2409590 | - | 714 | Protein_2371 | thiamine pyrophosphate-dependent enzyme | - |
| L2I54_RS12460 (L2I54_12425) | 2409612..2410094 | + | 483 | WP_000191888.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| L2I54_RS12465 (L2I54_12430) | 2410261..2410998 | + | 738 | WP_000594152.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| L2I54_RS12470 (L2I54_12435) | 2411237..2411974 | + | 738 | WP_000624975.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| L2I54_RS12475 (L2I54_12440) | 2412087..2412215 | + | 129 | WP_000237819.1 | hypothetical protein | Antitoxin |
| L2I54_RS12480 (L2I54_12445) | 2412288..2412464 | + | 177 | WP_000852629.1 | stage II sporulation protein SB | - |
| L2I54_RS12485 (L2I54_12450) | 2412481..2412870 | - | 390 | WP_000713868.1 | YxeA family protein | - |
| L2I54_RS12490 (L2I54_12455) | 2413082..2414551 | + | 1470 | WP_000287549.1 | beta-Ala-His dipeptidase | - |
| L2I54_RS12495 (L2I54_12460) | 2414797..2415606 | + | 810 | WP_000678369.1 | papain-like cysteine protease family protein | - |
| L2I54_RS12500 (L2I54_12465) | 2415632..2416234 | + | 603 | WP_061457208.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28278.98 Da Isoelectric Point: 8.2998
>T233375 WP_000624975.1 NZ_CP091476:2411237-2411974 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMAIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMAIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T233375 NZ_HG813240:2925774-2926214 [Mycobacterium tuberculosis 49-02]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA
Antitoxin
Download Length: 43 a.a. Molecular weight: 4953.36 Da Isoelectric Point: 3.9798
>AT233375 WP_000237819.1 NZ_CP091476:2412087-2412215 [Bacillus cereus]
VVKDYDNDFFKEGNEDTTDFSLIKGDTLQQVEELEEELKRKS
VVKDYDNDFFKEGNEDTTDFSLIKGDTLQQVEELEEELKRKS
Download Length: 129 bp
>AT233375 NZ_HG813240:2925500-2925787 [Mycobacterium tuberculosis 49-02]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|