Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-ArgA
Location 4824518..4825337 Replicon chromosome
Accession NZ_CP091470
Organism Klebsiella michiganensis strain KO_408

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag L3249_RS22980 Protein ID WP_004110819.1
Coordinates 4825080..4825337 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A2J5QA69
Locus tag L3249_RS22975 Protein ID WP_032693191.1
Coordinates 4824518..4825069 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3249_RS22945 (L3249_22970) 4820442..4821215 + 774 WP_088168442.1 Zygote formation protein zyg1 -
L3249_RS22950 (L3249_22975) 4821526..4821999 + 474 WP_032693194.1 hypothetical protein -
L3249_RS22955 (L3249_22980) 4822268..4822617 - 350 Protein_4514 type II toxin-antitoxin system VapC family toxin -
L3249_RS22960 (L3249_22985) 4822680..4822838 - 159 Protein_4515 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
L3249_RS22965 (L3249_22990) 4822872..4823618 - 747 WP_223226754.1 class I SAM-dependent methyltransferase -
L3249_RS22970 (L3249_22995) 4823994..4824404 - 411 Protein_4517 class I SAM-dependent methyltransferase -
L3249_RS22975 (L3249_23000) 4824518..4825069 - 552 WP_032693191.1 N-acetyltransferase Antitoxin
L3249_RS22980 (L3249_23005) 4825080..4825337 - 258 WP_004110819.1 YjhX family toxin Toxin
L3249_RS22985 (L3249_23010) 4826013..4827197 + 1185 WP_014228054.1 mannonate dehydratase -
L3249_RS22990 (L3249_23015) 4827271..4828746 + 1476 WP_195377635.1 fructuronate reductase -
L3249_RS22995 (L3249_23020) 4828885..4829661 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T233371 WP_004110819.1 NZ_CP091470:c4825337-4825080 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T233371 NZ_HG813240:c2850118-2849699 [Mycobacterium tuberculosis 49-02]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20154.00 Da        Isoelectric Point: 6.4903

>AT233371 WP_032693191.1 NZ_CP091470:c4825069-4824518 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQMVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPEAHKACWMLQRLSS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp

>AT233371 NZ_HG813240:c2850339-2850115 [Mycobacterium tuberculosis 49-02]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A2J5QA69

References