Detailed information of TA system TA233350

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2060494..2061140
• Replicon: chromosome
• Accession: NZ_CP091456
• Organism: Avibacterium sp. 20-132

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L4F93_RS09890
• Protein ID: WP_250350095.1
• Coordinates: 2060494..2060901 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: L4F93_RS09895
• Protein ID: WP_250350096.1
• Coordinates: 2060901..2061140 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L4F93_RS09865 (L4F93_09865)	2057100..2057498	+	399	WP_250349920.1	hypothetical protein	-
L4F93_RS09870 (L4F93_09870)	2057495..2057794	+	300	WP_250349921.1	hypothetical protein	-
L4F93_RS09875 (L4F93_09875)	2057808..2059304	+	1497	WP_250350092.1	conjugal transfer protein TraG N-terminal domain-containing protein	-
L4F93_RS09880 (L4F93_09880)	2059362..2059706	-	345	WP_250350093.1	DUF3742 family protein	-
L4F93_RS09885 (L4F93_09885)	2059719..2060399	-	681	WP_250350094.1	DUF4852 domain-containing protein	-
L4F93_RS09890 (L4F93_09890)	2060494..2060901	-	408	WP_250350095.1	tRNA(fMet)-specific endonuclease VapC	Toxin
L4F93_RS09895 (L4F93_09895)	2060901..2061140	-	240	WP_250350096.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L4F93_RS09900 (L4F93_09900)	2061277..2061711	-	435	WP_250350097.1	hypothetical protein	-
L4F93_RS09905 (L4F93_09905)	2061777..2063774	-	1998	WP_250350098.1	integrating conjugative element protein	-
L4F93_RS09910 (L4F93_09910)	2063786..2064688	-	903	WP_250351668.1	TIGR03756 family integrating conjugative element protein	-
L4F93_RS09915 (L4F93_09915)	2064714..2065151	-	438	WP_250349929.1	TIGR03757 family integrating conjugative element protein	-
L4F93_RS09920 (L4F93_09920)	2065533..2065883	+	351	WP_035686545.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	ompP5	2028478..2180241	151763

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15015.60 Da
• Isoelectric Point: 8.4769

>T233350 WP_250350095.1 NZ_CP091456:c2060901-2060494 [Avibacterium sp. 20-132]
MLKYMLDTNIAIFTIKNKPVHMLPLFNENQAMICMSSIALMELIYGAEKSAKVAHNLSIIESFCSRLTILNYDERAAYHS
GQIRAELAKQGQPIGPYDAMIAGHARSLGLTIVTNNIKEFSKVEGLKVVDWSKGI

Nucleotide

• Length: 408 bp

>T233350 NZ_HG813240:c1229591-1229280 [Mycobacterium tuberculosis 49-02]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9193.50 Da
• Isoelectric Point: 4.9681

>AT233350 WP_250350096.1 NZ_CP091456:c2061140-2060901 [Avibacterium sp. 20-132]
MSIVTATIFMNNKSQAIRIPKTAELPEKIKNVNIIVQGNTRIITPINTVWDSWFNDVHTVSDDFMLDREQPQMQERESF

Nucleotide

• Length: 240 bp

>AT233350 NZ_HG813240:c1229911-1229591 [Mycobacterium tuberculosis 49-02]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A