Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1363992..1364607 Replicon chromosome
Accession NZ_CP091456
Organism Avibacterium sp. 20-132

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag L4F93_RS06495 Protein ID WP_250349542.1
Coordinates 1363992..1364174 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L4F93_RS06500 Protein ID WP_250349543.1
Coordinates 1364200..1364607 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4F93_RS06475 (L4F93_06475) 1359757..1360962 - 1206 WP_250349539.1 low temperature requirement protein A -
L4F93_RS06480 (L4F93_06480) 1360976..1361524 - 549 WP_250349540.1 DUF924 family protein -
L4F93_RS06485 (L4F93_06485) 1361703..1361921 + 219 WP_005627617.1 translation initiation factor IF-1 -
L4F93_RS06490 (L4F93_06490) 1362038..1363894 + 1857 WP_250349541.1 ATP-binding protein -
L4F93_RS06495 (L4F93_06495) 1363992..1364174 + 183 WP_250349542.1 type II toxin-antitoxin system HicA family toxin Toxin
L4F93_RS06500 (L4F93_06500) 1364200..1364607 + 408 WP_250349543.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L4F93_RS06505 (L4F93_06505) 1364735..1366198 + 1464 WP_250349544.1 sucrose-specific PTS transporter subunit IIBC -
L4F93_RS06510 (L4F93_06510) 1366325..1366726 + 402 WP_250349545.1 NUDIX domain-containing protein -
L4F93_RS06515 (L4F93_06515) 1366927..1368273 + 1347 WP_250349546.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6726.93 Da        Isoelectric Point: 11.1590

>T233347 WP_250349542.1 NZ_CP091456:1363992-1364174 [Avibacterium sp. 20-132]
VNSANLIKQIENDGWQLIAVKGSHHQFKHSIKKGRVTIPHPKKDLPLKTVHSILKQAGLK

Download         Length: 183 bp

>T233347 NZ_HG813240:c754704-754267 [Mycobacterium tuberculosis 49-02]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15098.24 Da        Isoelectric Point: 4.6700

>AT233347 WP_250349543.1 NZ_CP091456:1364200-1364607 [Avibacterium sp. 20-132]
MLYPIGIEMGDENHAYGVIVPDVPGCFSAGDTLEEAFANAKEAITFHIEGMIEDGEDIPLPTDLQRHMKNKEYEAFTFTV
VDVDLTHLMGKTEKINVTLPKRLINKIDRYVATHPEYKSRSGFLAQIATDKLLTA

Download         Length: 408 bp

>AT233347 NZ_HG813240:c754955-754701 [Mycobacterium tuberculosis 49-02]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References