Detailed information of TA system TA233346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 499798..500338
• Replicon: chromosome
• Accession: NZ_CP091456
• Organism: Avibacterium sp. 20-132

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L4F93_RS02280
• Protein ID: WP_250350932.1
• Coordinates: 500048..500338 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: L4F93_RS02275
• Protein ID: WP_250350931.1
• Coordinates: 499798..500058 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L4F93_RS02260 (L4F93_02260)	495393..498827	-	3435	WP_250351604.1	transcription-repair coupling factor	-
L4F93_RS02270 (L4F93_02270)	499376..499666	+	291	WP_250350930.1	Arm DNA-binding domain-containing protein	-
L4F93_RS02275 (L4F93_02275)	499798..500058	+	261	WP_250350931.1	stability protein StbD	Antitoxin
L4F93_RS02280 (L4F93_02280)	500048..500338	+	291	WP_250350932.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L4F93_RS02285 (L4F93_02285)	500620..501570	-	951	WP_250350933.1	cysteine synthase A	-
L4F93_RS02290 (L4F93_02290)	501689..502537	-	849	WP_250350934.1	sulfate transporter CysZ	-
L4F93_RS02295 (L4F93_02295)	502687..503679	+	993	WP_250350935.1	cell division protein ZipA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11405.44 Da
• Isoelectric Point: 10.7847

>T233346 WP_250350932.1 NZ_CP091456:500048-500338 [Avibacterium sp. 20-132]
MTYKLLFDKRALKEWQKLGDTLRQQFKAKLIERLENPHVPSDKLHGYQTLYKIKLRSAGYRLVYDVNDNKITVIVLSVGK
RNRLEAYKKALLRKTQ

Nucleotide

• Length: 291 bp

>T233346 NZ_HG813240:c754704-754267 [Mycobacterium tuberculosis 49-02]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9433.87 Da
• Isoelectric Point: 4.3076

>AT233346 WP_250350931.1 NZ_CP091456:499798-500058 [Avibacterium sp. 20-132]
MAIHQILTRHTASISDLKKNPMGIVSEGTVEEGAIAILNRNEPVFYCINPALFAAIQEMLEDKELGEIATKRLATLDPVE
VSLDDL

Nucleotide

• Length: 261 bp

>AT233346 NZ_HG813240:c754157-753912 [Mycobacterium tuberculosis 49-02]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA