Detailed information of TA system TA233343

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3479648..3480301
• Replicon: chromosome
• Accession: NZ_CP091452
• Organism: Acinetobacter baumannii strain AB329

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LGY76_RS16855
• Protein ID: WP_000607077.1
• Coordinates: 3479648..3480037 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: LGY76_RS16860
• Protein ID: WP_001288210.1
• Coordinates: 3480044..3480301 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGY76_RS16840	3474766..3476961	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
LGY76_RS16845	3477149..3477715	-	567	WP_000651538.1	rhombosortase	-
LGY76_RS16850	3477793..3478878	-	1086	WP_000049106.1	hypothetical protein	-
LGY76_RS16855	3479648..3480037	-	390	WP_000607077.1	membrane protein	Toxin
LGY76_RS16860	3480044..3480301	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
LGY76_RS16865	3480489..3481661	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
LGY76_RS16870	3481710..3483200	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
LGY76_RS16875	3483382..3483759	-	378	WP_001216380.1	50S ribosomal protein L17	-
LGY76_RS16880	3483778..3484785	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233343 WP_000607077.1 NZ_CP091452:c3480037-3479648 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233343 NZ_HG813240:716681-717088 [Mycobacterium tuberculosis 49-02]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233343 WP_001288210.1 NZ_CP091452:c3480301-3480044 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233343 NZ_HG813240:716424-716684 [Mycobacterium tuberculosis 49-02]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7