Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1619024..1619692 Replicon chromosome
Accession NZ_CP091451
Organism Streptococcus pneumoniae strain 3238/09

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag L3475_RS08245 Protein ID WP_001132282.1
Coordinates 1619513..1619692 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag L3475_RS08240 Protein ID WP_000961810.1
Coordinates 1619024..1619476 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3475_RS08220 (L3475_08155) 1615873..1616907 - 1035 WP_000747915.1 ATP-binding protein -
L3475_RS08225 (L3475_08160) 1617041..1617175 - 135 Protein_1628 7,8-dihydro-8-oxoguanine-triphosphatase -
L3475_RS08230 (L3475_08165) 1617156..1618244 - 1089 WP_000719711.1 site-2 protease family protein -
L3475_RS08235 (L3475_08170) 1618263..1618733 - 471 WP_000257114.1 DUF3013 family protein -
L3475_RS08240 (L3475_08175) 1619024..1619476 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L3475_RS08245 (L3475_08180) 1619513..1619692 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
L3475_RS08250 (L3475_08185) 1619829..1620008 - 180 WP_001048906.1 hypothetical protein -
L3475_RS08255 (L3475_08190) 1620173..1620412 - 240 WP_000818079.1 hypothetical protein -
L3475_RS08260 (L3475_08195) 1620682..1621953 + 1272 WP_001113206.1 replication-associated recombination protein A -
L3475_RS08270 (L3475_08205) 1622500..1623819 - 1320 WP_000502563.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T233342 WP_001132282.1 NZ_CP091451:c1619692-1619513 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T233342 NZ_HG813240:715063-715458 [Mycobacterium tuberculosis 49-02]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT233342 WP_000961810.1 NZ_CP091451:c1619476-1619024 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT233342 NZ_HG813240:714809-715063 [Mycobacterium tuberculosis 49-02]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References