Detailed information of TA system TA233341

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 943004..943502
• Replicon: chromosome
• Accession: NZ_CP091451
• Organism: Streptococcus pneumoniae strain 3238/09

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L3475_RS04870
• Protein ID: WP_001812387.1
• Coordinates: 943248..943502 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: L3475_RS04865
• Protein ID: WP_000208080.1
• Coordinates: 943004..943246 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L3475_RS04845 (L3475_04800)	938826..940001	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
L3475_RS04850 (L3475_04805)	940056..940760	+	705	WP_000722076.1	response regulator YycF	-
L3475_RS04855 (L3475_04810)	940753..942102	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
L3475_RS04860 (L3475_04815)	942104..942913	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
L3475_RS04865 (L3475_04820)	943004..943246	+	243	WP_000208080.1	DUF6290 family protein	Antitoxin
L3475_RS04870 (L3475_04825)	943248..943502	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L3475_RS04875 (L3475_04830)	943549..944322	+	774	WP_000731129.1	ion channel	-
L3475_RS04880 (L3475_04835)	944638..945984	-	1347	WP_001821303.1	IS1380-like element ISSpn5 family transposase	-
L3475_RS04885 (L3475_04840)	946293..947279	-	987	WP_000204727.1	L-lactate dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	944638..945984	1346

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T233341 WP_001812387.1 NZ_CP091451:943248-943502 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T233341 NZ_HG813240:709405-709806 [Mycobacterium tuberculosis 49-02]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT233341 WP_000208080.1 NZ_CP091451:943004-943246 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT233341 NZ_HG813240:709181-709408 [Mycobacterium tuberculosis 49-02]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7