Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1585028..1585696 Replicon chromosome
Accession NZ_CP091450
Organism Streptococcus pneumoniae strain 3641/15

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag L3474_RS07925 Protein ID WP_001132282.1
Coordinates 1585517..1585696 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag L3474_RS07920 Protein ID WP_000961810.1
Coordinates 1585028..1585480 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3474_RS07900 (L3474_07845) 1581877..1582911 - 1035 WP_000747915.1 ATP-binding protein -
L3474_RS07905 (L3474_07850) 1583045..1583179 - 135 Protein_1564 7,8-dihydro-8-oxoguanine-triphosphatase -
L3474_RS07910 (L3474_07855) 1583160..1584248 - 1089 WP_000719711.1 site-2 protease family protein -
L3474_RS07915 (L3474_07860) 1584267..1584737 - 471 WP_000257114.1 DUF3013 family protein -
L3474_RS07920 (L3474_07865) 1585028..1585480 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L3474_RS07925 (L3474_07870) 1585517..1585696 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
L3474_RS07930 (L3474_07875) 1585833..1586012 - 180 WP_001048906.1 hypothetical protein -
L3474_RS07935 (L3474_07880) 1586177..1586416 - 240 WP_000818079.1 hypothetical protein -
L3474_RS07940 (L3474_07885) 1586686..1587957 + 1272 WP_001113206.1 replication-associated recombination protein A -
L3474_RS07950 (L3474_07895) 1588504..1589823 - 1320 WP_000502563.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T233340 WP_001132282.1 NZ_CP091450:c1585696-1585517 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T233340 NZ_HG813240:701885-702286 [Mycobacterium tuberculosis 49-02]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT233340 WP_000961810.1 NZ_CP091450:c1585480-1585028 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT233340 NZ_HG813240:701643-701888 [Mycobacterium tuberculosis 49-02]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References