Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2116836..2117479 Replicon chromosome
Accession NZ_CP091442
Organism Pseudoalteromonas sp. CF6-2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag L3Q70_RS20340 Protein ID WP_267145280.1
Coordinates 2116836..2116970 (+) Length 45 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L3Q70_RS09850 Protein ID WP_237114183.1
Coordinates 2117063..2117479 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Q70_RS09820 (L3Q70_09820) 2112646..2113437 - 792 WP_237114179.1 MBL fold metallo-hydrolase -
L3Q70_RS09825 (L3Q70_09825) 2113573..2114475 - 903 WP_237114180.1 potassium channel family protein -
L3Q70_RS09830 (L3Q70_09830) 2114882..2115055 - 174 WP_165381462.1 hypothetical protein -
L3Q70_RS09835 (L3Q70_09835) 2115092..2115766 - 675 WP_237114181.1 hypothetical protein -
L3Q70_RS09840 (L3Q70_09840) 2115886..2116467 - 582 WP_237114182.1 hypothetical protein -
L3Q70_RS20340 2116836..2116970 + 135 WP_267145280.1 type II toxin-antitoxin system HicA family toxin Toxin
L3Q70_RS20345 2116937..2117014 + 78 WP_267145288.1 type II toxin-antitoxin system HicA family toxin -
L3Q70_RS09850 (L3Q70_09850) 2117063..2117479 + 417 WP_237114183.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L3Q70_RS09855 (L3Q70_09855) 2117911..2119362 + 1452 WP_237114184.1 exodeoxyribonuclease I -
L3Q70_RS09860 (L3Q70_09860) 2119408..2120289 - 882 WP_193987455.1 NAD(P)-dependent oxidoreductase -
L3Q70_RS09865 (L3Q70_09865) 2120404..2120919 + 516 WP_193987456.1 redoxin domain-containing protein -
L3Q70_RS09870 (L3Q70_09870) 2120885..2121868 + 984 WP_237115257.1 2-hydroxyacid dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-32)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 5139.92 Da        Isoelectric Point: 10.4733

>T233337 WP_267145280.1 NZ_CP091442:2116836-2116970 [Pseudoalteromonas sp. CF6-2]
VNSKDLIKQLEQAVWQEVRVKGSHHHFRHPTIATCSPYLTLRKS

Download         Length: 135 bp

>T233337 NZ_HG813240:676320-676727 [Mycobacterium tuberculosis 49-02]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15067.14 Da        Isoelectric Point: 4.5457

>AT233337 WP_237114183.1 NZ_CP091442:2117063-2117479 [Pseudoalteromonas sp. CF6-2]
MLYPVAIEKGTSTEAFGVVFPDVQGCYSAGDSFEQALLNAKEALDTHLELLAGDGILPPQASNIDDHIKNPEFAGWVWAL
VDIDLEPYLGKAGKINVTLPNLLTKQIDDLVKAHPHYKSRSNFLQLAAMHEIQNISAP

Download         Length: 417 bp

>AT233337 NZ_HG813240:676108-676323 [Mycobacterium tuberculosis 49-02]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References