Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 1238736..1239371 Replicon chromosome
Accession NZ_CP091430
Organism Paenibacillus sp. PHS-Z3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag L1F29_RS05540 Protein ID WP_090581240.1
Coordinates 1239021..1239371 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag L1F29_RS05535 Protein ID WP_204821574.1
Coordinates 1238736..1239017 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F29_RS05515 (L1F29_05495) 1234647..1235243 + 597 WP_258387362.1 TetR/AcrR family transcriptional regulator -
L1F29_RS05520 (L1F29_05500) 1235459..1235614 - 156 WP_258387363.1 hypothetical protein -
L1F29_RS05525 (L1F29_05505) 1235698..1236939 + 1242 WP_258387364.1 DUF4367 domain-containing protein -
L1F29_RS05530 (L1F29_05510) 1237214..1238398 + 1185 WP_258387365.1 alanine racemase -
L1F29_RS05535 (L1F29_05515) 1238736..1239017 + 282 WP_204821574.1 ribbon-helix-helix protein, CopG family Antitoxin
L1F29_RS05540 (L1F29_05520) 1239021..1239371 + 351 WP_090581240.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
L1F29_RS05545 (L1F29_05525) 1239659..1240282 + 624 WP_258387366.1 YhbD family protein -
L1F29_RS05550 (L1F29_05530) 1240295..1240975 + 681 WP_258387367.1 polymer-forming cytoskeletal protein -
L1F29_RS05555 (L1F29_05535) 1241018..1241689 + 672 WP_258387368.1 bactofilin -
L1F29_RS05560 (L1F29_05540) 1241726..1243285 + 1560 WP_258389615.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12832.80 Da        Isoelectric Point: 5.1284

>T233336 WP_090581240.1 NZ_CP091430:1239021-1239371 [Paenibacillus sp. PHS-Z3]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAALHGFDRDSVLLLEQI
RTIDKQRLTDKITHLDDETMRKVDEALQISVGLIDF

Download         Length: 351 bp

>T233336 NZ_HG813240:c639045-638632 [Mycobacterium tuberculosis 49-02]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10600.20 Da        Isoelectric Point: 5.8719

>AT233336 WP_204821574.1 NZ_CP091430:1238736-1239017 [Paenibacillus sp. PHS-Z3]
VANMQNTKRIMISLPDHLLEEVDGIVARENSNRSEFIRQAMKLYLVERKKRQIRESMQRGYLEMAMINLGMASEAFQAEE
DAGDTLGRLVSGV

Download         Length: 282 bp

>AT233336 NZ_HG813240:c639308-639042 [Mycobacterium tuberculosis 49-02]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References