Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2136012..2136650 Replicon chromosome
Accession NZ_CP091427
Organism Escherichia coli strain 1000C-3

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag L3Z43_RS10295 Protein ID WP_001447010.1
Coordinates 2136012..2136188 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L3Z43_RS10300 Protein ID WP_001270286.1
Coordinates 2136234..2136650 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Z43_RS10275 (2131631) 2131631..2132806 - 1176 WP_001236265.1 BenE family transporter YdcO -
L3Z43_RS10280 (2132898) 2132898..2133434 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
L3Z43_RS10285 (2133507) 2133507..2135468 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
L3Z43_RS10290 (2135560) 2135560..2135790 - 231 WP_000494244.1 YncJ family protein -
L3Z43_RS10295 (2136012) 2136012..2136188 + 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
L3Z43_RS10300 (2136234) 2136234..2136650 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
L3Z43_RS10305 (2136729) 2136729..2138135 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
L3Z43_RS10310 (2138380) 2138380..2139525 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
L3Z43_RS10315 (2139543) 2139543..2140556 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
L3Z43_RS10320 (2140557) 2140557..2141498 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T233310 WP_001447010.1 NZ_CP091427:2136012-2136188 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT233310 WP_001270286.1 NZ_CP091427:2136234-2136650 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References