Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 905146..905981 Replicon chromosome
Accession NZ_CP091427
Organism Escherichia coli strain 1000C-3

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag L3Z43_RS04290 Protein ID WP_042047257.1
Coordinates 905604..905981 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag L3Z43_RS04285 Protein ID WP_001295723.1
Coordinates 905146..905514 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Z43_RS04255 (901982) 901982..902437 + 456 WP_000581504.1 IrmA family protein -
L3Z43_RS04260 (902516) 902516..902749 + 234 WP_001119729.1 DUF905 family protein -
L3Z43_RS04265 (902849) 902849..903667 + 819 WP_001234620.1 DUF932 domain-containing protein -
L3Z43_RS04270 (903722) 903722..904207 + 486 WP_000849588.1 antirestriction protein -
L3Z43_RS04275 (904223) 904223..904699 + 477 WP_001186774.1 RadC family protein -
L3Z43_RS04280 (904762) 904762..904983 + 222 WP_000692311.1 DUF987 domain-containing protein -
L3Z43_RS04285 (905146) 905146..905514 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L3Z43_RS04290 (905604) 905604..905981 + 378 WP_042047257.1 TA system toxin CbtA family protein Toxin
L3Z43_RS04295 (905978) 905978..906466 + 489 WP_116290099.1 DUF5983 family protein -
L3Z43_RS04300 (906478) 906478..906675 + 198 WP_000839267.1 DUF957 domain-containing protein -
L3Z43_RS04305 (906760) 906760..907608 + 849 WP_042047262.1 DUF4942 domain-containing protein -
L3Z43_RS04310 (907701) 907701..908348 - 648 WP_239804094.1 site-specific integrase -
L3Z43_RS04315 (908492) 908492..909654 + 1163 WP_085949416.1 IS3-like element IS3 family transposase -
L3Z43_RS04320 (909682) 909682..910281 - 600 WP_239804095.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14211.22 Da        Isoelectric Point: 7.2652

>T233308 WP_042047257.1 NZ_CP091427:905604-905981 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T233308 NZ_HG738867:3081186-3081293 [Escherichia coli str. K-12 substr. MC4100]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT233308 WP_001295723.1 NZ_CP091427:905146-905514 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT233308 NZ_HG738867:c3081137-3081071 [Escherichia coli str. K-12 substr. MC4100]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References