Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 49127..49668 Replicon plasmid unnamed2
Accession NZ_CP091426
Organism Methylobacter sp. YRD-M1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LZ558_RS22650 Protein ID WP_268121144.1
Coordinates 49127..49414 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LZ558_RS22655 Protein ID WP_268121145.1
Coordinates 49411..49668 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ558_RS22635 (LZ558_22565) 44276..45631 - 1356 WP_268121141.1 restriction endonuclease subunit S -
LZ558_RS22640 (LZ558_22570) 45624..46721 - 1098 WP_268121142.1 PDDEXK nuclease domain-containing protein -
LZ558_RS22645 (LZ558_22575) 46731..49100 - 2370 WP_268121143.1 class I SAM-dependent DNA methyltransferase -
LZ558_RS22650 (LZ558_22580) 49127..49414 - 288 WP_268121144.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ558_RS22655 (LZ558_22585) 49411..49668 - 258 WP_268121145.1 CopG family ribbon-helix-helix protein Antitoxin
LZ558_RS22660 (LZ558_22590) 49733..49969 - 237 WP_268121146.1 WGR domain-containing protein -
LZ558_RS22665 (LZ558_22595) 50051..51397 - 1347 WP_268121148.1 hypothetical protein -
LZ558_RS22670 (LZ558_22600) 51430..52470 - 1041 WP_268121149.1 tyrosine-type recombinase/integrase -
LZ558_RS22675 (LZ558_22605) 52676..52870 + 195 WP_268121150.1 hypothetical protein -
LZ558_RS22680 (LZ558_22610) 52945..53115 + 171 WP_268121151.1 hypothetical protein -
LZ558_RS22685 (LZ558_22615) 53203..53481 + 279 WP_268121152.1 hypothetical protein -
LZ558_RS22690 (LZ558_22620) 53566..54366 + 801 WP_268121153.1 retropepsin-like aspartic protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..61761 61761


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-83)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11033.74 Da        Isoelectric Point: 6.8489

>T233302 WP_268121144.1 NZ_CP091426:c49414-49127 [Methylobacter sp. YRD-M1]
VKIVWTEPARHDLHEIFEYITEEDPHAARTLLNKIKDHVLFLLNNPQIGQVGRVEGTRELVLAGTHFILPYRLKDQQIQI
LAVFHVEKMVGSFHN

Download         Length: 288 bp

>T233302 NZ_HG738867:c1480705-1479383 [Escherichia coli str. K-12 substr. MC4100]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9670.86 Da        Isoelectric Point: 5.5124

>AT233302 WP_268121145.1 NZ_CP091426:c49668-49411 [Methylobacter sp. YRD-M1]
MATEAFTVRTESDLVHQLDQLADSLDRSRNYVVNQALKEYLAHHAWQIEKTTQGIAAAVRGELVDHDEVVKEMEDLIKHK
TQGKV

Download         Length: 258 bp

>AT233302 NZ_HG738867:c1480971-1480705 [Escherichia coli str. K-12 substr. MC4100]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References