Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 230568..232081 Replicon plasmid unnamed1
Accession NZ_CP091425
Organism Methylobacter sp. YRD-M1

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag LZ558_RS21875 Protein ID WP_268120927.1
Coordinates 231164..232081 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag LZ558_RS21870 Protein ID WP_268120926.1
Coordinates 230568..231167 (+) Length 200 a.a.

Genomic Context

LZ558_RS21835LZ558_RS21865LZ558_RS21870LZ558_RS21875LZ558_RS21880LZ558_RS21840LZ558_RS21845LZ558_RS21850LZ558_RS21855LZ558_RS21860LZ558_RS21885LZ558_RS21890LZ558_RS21895LZ558_RS21900LZ558_RS21905
Location: 226240..226767 (528 bp)
Type: Others
Protein ID: WP_268120920.1
Location: 230103..230370 (268 bp)
Type: Others
Protein ID: Protein_224
Location: 230568..231167 (600 bp)
Type: Antitoxin
Protein ID: WP_268120926.1
Location: 231164..232081 (918 bp)
Type: Toxin
Protein ID: WP_268120927.1
Location: 232477..233159 (683 bp)
Type: Others
Protein ID: WP_268120928.1
Location: 226906..227598 (693 bp)
Type: Others
Protein ID: WP_268120921.1
Location: 227694..228209 (516 bp)
Type: Others
Protein ID: WP_268120922.1
Location: 228225..229109 (885 bp)
Type: Others
Protein ID: WP_268120923.1
Location: 229112..229516 (405 bp)
Type: Others
Protein ID: WP_268120924.1
Location: 229805..229936 (132 bp)
Type: Others
Protein ID: WP_268120925.1
Location: 233495..233728 (234 bp)
Type: Others
Protein ID: WP_268120929.1
Location: 233766..234164 (399 bp)
Type: Others
Protein ID: WP_268120930.1
Location: 234210..235877 (1668 bp)
Type: Others
Protein ID: WP_268120931.1
Location: 235894..236739 (846 bp)
Type: Others
Protein ID: WP_268120932.1
Location: 236791..237078 (288 bp)
Type: Others
Protein ID: WP_268120933.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LZ558_RS21835 (LZ558_21775)226240..226767+528WP_268120920.1hypothetical protein-
LZ558_RS21840 (LZ558_21780)226906..227598-693WP_268120921.1hypothetical protein-
LZ558_RS21845 (LZ558_21785)227694..228209-516WP_268120922.1SMI1/KNR4 family protein-
LZ558_RS21850 (LZ558_21790)228225..229109-885WP_268120923.1HNH endonuclease-
LZ558_RS21855 (LZ558_21795)229112..229516-405WP_268120924.1hypothetical protein-
LZ558_RS21860229805..229936-132WP_268120925.1hypothetical protein-
LZ558_RS21865 (LZ558_21800)230103..230370+268Protein_224replication protein-
LZ558_RS21870 (LZ558_21805)230568..231167+600WP_268120926.1AbiEi antitoxin N-terminal domain-containing proteinAntitoxin
LZ558_RS21875 (LZ558_21810)231164..232081+918WP_268120927.1nucleotidyl transferase AbiEii/AbiGii toxin family proteinToxin
LZ558_RS21880 (LZ558_21815)232477..233159+683WP_268120928.1IS1 family transposase-
LZ558_RS21885 (LZ558_21820)233495..233728-234WP_268120929.1hypothetical protein-
LZ558_RS21890 (LZ558_21825)233766..234164-399WP_268120930.1cupin domain-containing protein-
LZ558_RS21895 (LZ558_21830)234210..235877-1668WP_268120931.1sigma 54-interacting transcriptional regulator-
LZ558_RS21900 (LZ558_21835)235894..236739-846WP_268120932.1ZIP family metal transporter-
LZ558_RS21905 (LZ558_21840)236791..237078-288WP_268120933.1zinc ribbon domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..349359349359


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-262)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-53)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34385.42 Da        Isoelectric Point: 6.3473

>T233301 WP_268120927.1 NZ_CP091425:231164-232081 [Methylobacter sp. YRD-M1]
MTNGNIAASVRNRLLNHARTKRQDFNLVLTRYAIERLLYRISISKYADQFLLKGALLFDLWFDIPHRPTRDADFLSFGSA
DLTYIEGIFKDICELDVLDGMAFQSATVRAAEIRKEAHYAGVRVTLLGLLDGARCQVQVDMGFGDAVTPGPEEATYPVIL
SEFAAPKLSAYPRYTVVAEKFEALSSLGIANSRMKDYFDLWILACHTDFEGDILCQAVRTTFERRKTMLLDQLPFGLTET
FAQDAQKQVQWQAFLRKNKLDALALEEVVSQLAVFMRPVVDAASTHQAFSWLWQAGGPWRPTSPS

Download         Length: 918 bp

>T233301 NZ_HG738867:1397815-1397991 [Escherichia coli str. K-12 substr. MC4100]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22698.34 Da        Isoelectric Point: 10.0418

>AT233301 WP_268120926.1 NZ_CP091425:230568-231167 [Methylobacter sp. YRD-M1]
MENTYQRILDFAHTHALIRPSDLAAQGLPRVALTRLVRRGQLIRISRGLYARPDRPVSEHGALAETARKYPHAIVCLLSA
LRFHDLTTQSPFEVWLAIPNKARAPRIDYPPLRIIRFSGAALTEGVEVHQIDGVPVRITNVARTVADCFKYRNKIGLEVA
LEALHESWREKRVSMDELWHYASLCRVANVMRPYMESLP

Download         Length: 600 bp

>AT233301 NZ_HG738867:1398037-1398453 [Escherichia coli str. K-12 substr. MC4100]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References