Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2507093..2507653 Replicon chromosome
Accession NZ_CP091424
Organism Methylobacter sp. YRD-M1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LZ558_RS10995 Protein ID WP_268116989.1
Coordinates 2507363..2507653 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LZ558_RS10990 Protein ID WP_268116988.1
Coordinates 2507093..2507290 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ558_RS10970 (LZ558_10935) 2502899..2503688 + 790 WP_268116984.1 IS5 family transposase -
LZ558_RS10975 (LZ558_10940) 2503816..2504148 - 333 WP_268116985.1 hypothetical protein -
LZ558_RS10980 (LZ558_10945) 2504179..2505861 - 1683 WP_268116986.1 cation:proton antiporter -
LZ558_RS10985 (LZ558_10950) 2506040..2506654 - 615 WP_268116987.1 recombinase family protein -
LZ558_RS10990 (LZ558_10955) 2507093..2507290 + 198 WP_268116988.1 ribbon-helix-helix protein, CopG family Antitoxin
LZ558_RS10995 (LZ558_10960) 2507363..2507653 + 291 WP_268116989.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ558_RS11000 (LZ558_10965) 2507876..2508514 - 639 WP_268116990.1 pyridoxamine 5'-phosphate oxidase family protein -
LZ558_RS11005 (LZ558_10970) 2508537..2509109 - 573 WP_268116991.1 TetR/AcrR family transcriptional regulator -
LZ558_RS11010 (LZ558_10975) 2509241..2509630 + 390 WP_268116992.1 hypothetical protein -
LZ558_RS11015 (LZ558_10980) 2509961..2511511 - 1551 WP_268116993.1 serine/threonine-protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(1-92)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10677.16 Da        Isoelectric Point: 6.2164

>T233299 WP_268116989.1 NZ_CP091424:2507363-2507653 [Methylobacter sp. YRD-M1]
VIVTARAAQSLEHCRRFLTEKNPQALMRAGQAIASRFSLLETEPGIGRPLDELPELRELIIPFGDSGYVALYHVDASADA
VYVLAFRHQKEAGYYS

Download         Length: 291 bp

>T233299 NZ_HG738867:c1157513-1157406 [Escherichia coli str. K-12 substr. MC4100]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7760.91 Da        Isoelectric Point: 11.0383

>AT233299 WP_268116988.1 NZ_CP091424:2507093-2507290 [Methylobacter sp. YRD-M1]
MATSVKLDDDLKNRIQHLAEMRHRSAHWIMREAIRDYVEREGKRGKLSNRRPWHPGQLIKKPDST

Download         Length: 198 bp

>AT233299 NZ_HG738867:1157560-1157626 [Escherichia coli str. K-12 substr. MC4100]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References