Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 994953..995518 Replicon chromosome
Accession NZ_CP091424
Organism Methylobacter sp. YRD-M1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LZ558_RS04505 Protein ID WP_268119644.1
Coordinates 995147..995518 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LZ558_RS04500 Protein ID WP_268119643.1
Coordinates 994953..995150 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ558_RS04470 (LZ558_04445) 990987..991490 + 504 WP_268119637.1 CinA family protein -
LZ558_RS04475 (LZ558_04450) 991529..993037 - 1509 WP_268119639.1 hypothetical protein -
LZ558_RS04480 (LZ558_04455) 993286..993576 - 291 Protein_887 pilin -
LZ558_RS04485 (LZ558_04460) 993568..993693 - 126 Protein_888 prepilin-type N-terminal cleavage/methylation domain-containing protein -
LZ558_RS04490 (LZ558_04465) 994164..994406 + 243 WP_268119640.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LZ558_RS04495 (LZ558_04470) 994399..994791 + 393 WP_268119641.1 type II toxin-antitoxin system VapC family toxin -
LZ558_RS04500 (LZ558_04475) 994953..995150 + 198 WP_268119643.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LZ558_RS04505 (LZ558_04480) 995147..995518 + 372 WP_268119644.1 type II toxin-antitoxin system VapC family toxin Toxin
LZ558_RS04510 (LZ558_04485) 995655..996176 - 522 WP_268119645.1 DUF1264 domain-containing protein -
LZ558_RS04515 (LZ558_04490) 996954..997367 + 414 WP_268119646.1 hypothetical protein -
LZ558_RS04520 (LZ558_04495) 997401..998000 - 600 WP_268119647.1 hypothetical protein -
LZ558_RS04525 (LZ558_04500) 998121..998312 + 192 WP_268119648.1 hypothetical protein -
LZ558_RS04530 (LZ558_04505) 998342..999040 + 699 WP_268119649.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13672.99 Da        Isoelectric Point: 6.6400

>T233298 WP_268119644.1 NZ_CP091424:995147-995518 [Methylobacter sp. YRD-M1]
MILVDTSVWIDHLRRKDAELAAMLSEGQVLVHPWIIGELACGNLQDRKLVLDLLQSLPSASVASTGEVLFFIEKHVLMGR
GIGYVDVHLLAAARLAGTRLWTRDKRLVVVADELGMAYTETRH

Download         Length: 372 bp

>T233298 NZ_HG738867:c1156978-1156871 [Escherichia coli str. K-12 substr. MC4100]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7349.40 Da        Isoelectric Point: 11.0917

>AT233298 WP_268119643.1 NZ_CP091424:994953-995150 [Methylobacter sp. YRD-M1]
MRTTINIDDELLAQAQQLSGLTERTQLIREALRALVQRESARRLAQLGGTQPELKPVPRRQDINA

Download         Length: 198 bp

>AT233298 NZ_HG738867:1157025-1157091 [Escherichia coli str. K-12 substr. MC4100]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References