Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-couple_hipB |
| Location | 1377845..1379088 | Replicon | chromosome |
| Accession | NZ_CP091423 | ||
| Organism | Streptococcus suis strain LSM29 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | G7SEB4 |
| Locus tag | L3X15_RS06705 | Protein ID | WP_001235242.1 |
| Coordinates | 1377845..1378612 (-) | Length | 256 a.a. |
Antitoxin (Protein)
| Gene name | sezA | Uniprot ID | - |
| Locus tag | L3X15_RS06710 | Protein ID | WP_000578719.1 |
| Coordinates | 1378612..1379088 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L3X15_RS06690 (L3X15_06690) | 1374233..1374598 | - | 366 | WP_000431640.1 | MobC family plasmid mobilization relaxosome protein | - |
| L3X15_RS06695 (L3X15_06695) | 1374601..1374963 | - | 363 | WP_000140674.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| L3X15_RS06700 (L3X15_06700) | 1375301..1377844 | - | 2544 | WP_000601012.1 | AAA family ATPase | - |
| L3X15_RS06705 (L3X15_06705) | 1377845..1378612 | - | 768 | WP_001235242.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| L3X15_RS06710 (L3X15_06710) | 1378612..1379088 | - | 477 | WP_000578719.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| L3X15_RS06715 (L3X15_06715) | 1379158..1379448 | - | 291 | WP_000667951.1 | hypothetical protein | - |
| L3X15_RS06720 (L3X15_06720) | 1379498..1379887 | - | 390 | WP_044475264.1 | DUF5945 family protein | - |
| L3X15_RS06725 (L3X15_06725) | 1379884..1380111 | - | 228 | WP_000110922.1 | DUF5965 family protein | - |
| L3X15_RS06730 (L3X15_06730) | 1380139..1381239 | - | 1101 | WP_014636297.1 | toprim domain-containing protein | - |
| L3X15_RS06735 (L3X15_06735) | 1381279..1381917 | - | 639 | WP_237374670.1 | peptidylprolyl isomerase | - |
| L3X15_RS06740 (L3X15_06740) | 1382013..1382303 | - | 291 | WP_000893087.1 | DUF5966 family protein | - |
| L3X15_RS06745 (L3X15_06745) | 1382317..1382616 | - | 300 | WP_000079455.1 | DUF5962 family protein | - |
| L3X15_RS06750 (L3X15_06750) | 1382687..1383646 | - | 960 | Protein_1283 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | tet(40) / tet(O) | - | 1358368..1395655 | 37287 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 256 a.a. Molecular weight: 28985.80 Da Isoelectric Point: 5.1126
>T233295 WP_001235242.1 NZ_CP091423:c1378612-1377845 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
Download Length: 768 bp
>T233295 NZ_HG738867:c262892-262551 [Escherichia coli str. K-12 substr. MC4100]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
Antitoxin
Download Length: 159 a.a. Molecular weight: 18266.77 Da Isoelectric Point: 4.6424
>AT233295 WP_000578719.1 NZ_CP091423:c1379088-1378612 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
Download Length: 477 bp
>AT233295 NZ_HG738867:c263230-262913 [Escherichia coli str. K-12 substr. MC4100]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|