Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1348251..1348737 Replicon chromosome
Accession NZ_CP091423
Organism Streptococcus suis strain LSM29

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag L3X15_RS06570 Protein ID WP_011922754.1
Coordinates 1348251..1348520 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag L3X15_RS06575 Protein ID WP_002938604.1
Coordinates 1348510..1348737 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3X15_RS06545 (L3X15_06545) 1343304..1344221 - 918 WP_002937252.1 DNA-binding protein WhiA -
L3X15_RS06550 (L3X15_06550) 1344218..1345192 - 975 WP_002937257.1 YvcK family protein -
L3X15_RS06555 (L3X15_06555) 1345189..1346076 - 888 WP_011922160.1 RNase adapter RapZ -
L3X15_RS06560 (L3X15_06560) 1346098..1346475 - 378 WP_002937263.1 RidA family protein -
L3X15_RS06565 (L3X15_06565) 1346526..1347845 - 1320 WP_012775027.1 MATE family efflux transporter -
L3X15_RS06570 (L3X15_06570) 1348251..1348520 - 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L3X15_RS06575 (L3X15_06575) 1348510..1348737 - 228 WP_002938604.1 DUF6290 family protein Antitoxin
L3X15_RS06580 (L3X15_06580) 1349009..1350355 - 1347 WP_011922752.1 asparagine--tRNA ligase -
L3X15_RS06585 (L3X15_06585) 1350370..1351551 - 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
L3X15_RS06590 (L3X15_06590) 1351548..1352045 - 498 WP_011922751.1 DUF5590 domain-containing protein -
L3X15_RS06600 (L3X15_06600) 1353245..1353694 + 450 WP_009909619.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T233294 WP_011922754.1 NZ_CP091423:c1348520-1348251 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T233294 NZ_HG738867:252300-252698 [Escherichia coli str. K-12 substr. MC4100]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT233294 WP_002938604.1 NZ_CP091423:c1348737-1348510 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT233294 NZ_HG738867:252004-252297 [Escherichia coli str. K-12 substr. MC4100]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References