233293

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1099782..1100274 Replicon chromosome
Accession NZ_CP091423
Organism Streptococcus suis strain LSM29

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag L3X15_RS05405 Protein ID WP_011922404.1
Coordinates 1100017..1100274 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag L3X15_RS05400 Protein ID WP_012775104.1
Coordinates 1099782..1100033 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3X15_RS05380 (L3X15_05380) 1095349..1096095 + 747 WP_011922411.1 ABC transporter permease -
L3X15_RS05385 (L3X15_05385) 1096097..1096831 + 735 WP_011922410.1 ABC transporter permease -
L3X15_RS05390 (L3X15_05390) 1096967..1097719 + 753 WP_011922409.1 ABC transporter ATP-binding protein -
L3X15_RS05395 (L3X15_05395) 1097720..1099690 + 1971 WP_012775105.1 FtsX-like permease family protein -
L3X15_RS05400 (L3X15_05400) 1099782..1100033 + 252 WP_012775104.1 DUF6290 family protein Antitoxin
L3X15_RS05405 (L3X15_05405) 1100017..1100274 + 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L3X15_RS05410 (L3X15_05410) 1100313..1100978 + 666 WP_012775103.1 response regulator transcription factor -
L3X15_RS05415 (L3X15_05415) 1100975..1101916 + 942 WP_012775102.1 sensor histidine kinase -
L3X15_RS05420 (L3X15_05420) 1101992..1103500 + 1509 WP_237374646.1 phosphomannomutase/phosphoglucomutase -
L3X15_RS05425 (L3X15_05425) 1103563..1104633 - 1071 WP_044758798.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T233293 WP_011922404.1 NZ_CP091423:1100017-1100274 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T233293 NZ_HG738867:c246238-245960 [Escherichia coli str. K-12 substr. MC4100]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT233293 WP_012775104.1 NZ_CP091423:1099782-1100033 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT233293 NZ_HG738867:c246501-246241 [Escherichia coli str. K-12 substr. MC4100]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References