Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1265505..1265991 Replicon chromosome
Accession NZ_CP091422
Organism Streptococcus suis strain LSM157

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag L3X06_RS06205 Protein ID WP_011922754.1
Coordinates 1265505..1265774 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag L3X06_RS06210 Protein ID WP_002938604.1
Coordinates 1265764..1265991 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3X06_RS06180 (L3X06_06180) 1260558..1261475 - 918 WP_002937252.1 DNA-binding protein WhiA -
L3X06_RS06185 (L3X06_06185) 1261472..1262446 - 975 WP_002937257.1 YvcK family protein -
L3X06_RS06190 (L3X06_06190) 1262443..1263330 - 888 WP_011922160.1 RNase adapter RapZ -
L3X06_RS06195 (L3X06_06195) 1263352..1263729 - 378 WP_043029003.1 RidA family protein -
L3X06_RS06200 (L3X06_06200) 1263780..1265099 - 1320 WP_012775027.1 MATE family efflux transporter -
L3X06_RS06205 (L3X06_06205) 1265505..1265774 - 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L3X06_RS06210 (L3X06_06210) 1265764..1265991 - 228 WP_002938604.1 DUF6290 family protein Antitoxin
L3X06_RS06215 (L3X06_06215) 1266263..1267609 - 1347 WP_011922752.1 asparagine--tRNA ligase -
L3X06_RS06220 (L3X06_06220) 1267624..1268805 - 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
L3X06_RS06225 (L3X06_06225) 1268802..1269299 - 498 WP_011922751.1 DUF5590 domain-containing protein -
L3X06_RS06235 (L3X06_06235) 1270499..1270948 + 450 WP_009909619.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T233289 WP_011922754.1 NZ_CP091422:c1265774-1265505 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T233289 NZ_HG326223:c3118919-3118530 [Serratia marcescens subsp. marcescens Db11]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGCAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCCAAACGGCGGAACAAAGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCGGTGACGGTCTATGCATGGGATCGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGGGCAAACATGGGGAGAAAGGGCAAAATCATGGGCGCGATGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT233289 WP_002938604.1 NZ_CP091422:c1265991-1265764 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT233289 NZ_HG326223:c3119186-3118923 [Serratia marcescens subsp. marcescens Db11]
ATGGAAAGAATCGCCAAGCTGTTTAAAAACGGTAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTGTATATCCGTCGCGATCGGGAGGGAAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References