Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1015477..1015969 Replicon chromosome
Accession NZ_CP091422
Organism Streptococcus suis strain LSM157

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag L3X06_RS05035 Protein ID WP_011922404.1
Coordinates 1015712..1015969 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag L3X06_RS05030 Protein ID WP_012775104.1
Coordinates 1015477..1015728 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3X06_RS05010 (L3X06_05010) 1011044..1011790 + 747 WP_011922411.1 ABC transporter permease -
L3X06_RS05015 (L3X06_05015) 1011792..1012526 + 735 WP_011922410.1 ABC transporter permease -
L3X06_RS05020 (L3X06_05020) 1012662..1013414 + 753 WP_011922409.1 ABC transporter ATP-binding protein -
L3X06_RS05025 (L3X06_05025) 1013415..1015385 + 1971 WP_012775105.1 FtsX-like permease family protein -
L3X06_RS05030 (L3X06_05030) 1015477..1015728 + 252 WP_012775104.1 DUF6290 family protein Antitoxin
L3X06_RS05035 (L3X06_05035) 1015712..1015969 + 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L3X06_RS05040 (L3X06_05040) 1016008..1016673 + 666 WP_012775103.1 response regulator transcription factor -
L3X06_RS05045 (L3X06_05045) 1016670..1017611 + 942 WP_012775102.1 sensor histidine kinase -
L3X06_RS05050 (L3X06_05050) 1017687..1019195 + 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
L3X06_RS05055 (L3X06_05055) 1019265..1020335 - 1071 WP_043029021.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(O) / ant(6)-Ia / tet(M) - 918939..1022244 103305


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T233288 WP_011922404.1 NZ_CP091422:1015712-1015969 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T233288 NZ_HG326223:c3029145-3028789 [Serratia marcescens subsp. marcescens Db11]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAGTTCAATGCTGAAATTGTGCCTCACGGCCGCCAGGAAGGCAGCAAAGT
TGAGGCTGTAGCCAACCGCGTGCTCAATGCTTACCACTACGAGAACGTCACAGACGTTTACCGCTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGACGCAGAACTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTTGA
ACAAGCCGCTGAACACTTACGCCGGCTAACCGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT233288 WP_012775104.1 NZ_CP091422:1015477-1015728 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT233288 NZ_HG326223:c3029351-3029142 [Serratia marcescens subsp. marcescens Db11]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTTTTGGTCAAAGCCAAAGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References