Detailed information of TA system TA233287

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-couple_hipB
• Location: 968792..970044
• Replicon: chromosome
• Accession: NZ_CP091422
• Organism: Streptococcus suis strain LSM157

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A0Z9JWN4
• Locus tag: L3X06_RS04775
• Protein ID: WP_011922437.1
• Coordinates: 969268..970044 (+)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: sezA
• Uniprot ID: -
• Locus tag: L3X06_RS04770
• Protein ID: WP_012775115.1
• Coordinates: 968792..969268 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L3X06_RS04740 (L3X06_04740)	963962..964561	+	600	WP_011922444.1	response regulator transcription factor	-
L3X06_RS04745 (L3X06_04745)	965962..966600	+	639	WP_011922443.1	hypothetical protein	-
L3X06_RS04750 (L3X06_04750)	966639..967715	+	1077	WP_011922442.1	toprim domain-containing protein	-
L3X06_RS04755 (L3X06_04755)	967769..967996	+	228	WP_011922441.1	DUF5965 family protein	-
L3X06_RS04760 (L3X06_04760)	967993..968382	+	390	WP_011922440.1	DUF5945 family protein	-
L3X06_RS04765 (L3X06_04765)	968432..968722	+	291	WP_024379089.1	hypothetical protein	-
L3X06_RS04770 (L3X06_04770)	968792..969268	+	477	WP_012775115.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
L3X06_RS04775 (L3X06_04775)	969268..970044	+	777	WP_011922437.1	type II toxin-antitoxin system toxin PezT	Toxin
L3X06_RS04780 (L3X06_04780)	970041..972128	+	2088	WP_011922436.1	AAA family ATPase	-
L3X06_RS04785 (L3X06_04785)	972115..972738	+	624	Protein_897	UvrD-helicase domain-containing protein	-
L3X06_RS04790 (L3X06_04790)	972738..972917	+	180	Protein_898	DUF961 family protein	-
L3X06_RS04795 (L3X06_04795)	972946..974331	+	1386	WP_000813488.1	FtsK/SpoIIIE domain-containing protein	-
L3X06_RS04800 (L3X06_04800)	974334..974486	+	153	WP_000879507.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	erm(B) / tet(O) / ant(6)-Ia / tet(M)	-	918939..1022244	103305

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29171.98 Da
• Isoelectric Point: 5.2489

>T233287 WP_011922437.1 NZ_CP091422:969268-970044 [Streptococcus suis]
MRLEEFSEAAFQKALQRTIRALIRGKTIPEQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLSELEREQLFDQIQIYQRDRTCIYDSEIDEGSAVEVLQECLFGQWSKVEEEML
KAGQERLGELVSANGEKK

Nucleotide

• Length: 777 bp

>T233287 NZ_HG326223:2748573-2748752 [Serratia marcescens subsp. marcescens Db11]
ATGGATAGCAGGAATGCAATAGCAATGATTGAAGCCGATGGGTGGTATCTGGTGAGAGTTAAAGGCAGTCATCATCAGTT
CAAGCACCCAACGAAGAAAGGGCTGGTAACGGTAAAACATCCACAGAAAGACATACCGCTGCCAACACTGAAAAGTATCA
AGAAACAGGCGGGGCTCTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18282.69 Da
• Isoelectric Point: 4.4750

>AT233287 WP_012775115.1 NZ_CP091422:968792-969268 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT233287 NZ_HG326223:2748775-2749185 [Serratia marcescens subsp. marcescens Db11]
ATGTTGTATCCAGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATACCTGGCTGCTTCTCCGG
GGGCGACAACTATCAGGATGCGATCGAGAGTGCGCGCGAAGCCATCGAGGCGCATATCGAATTATTGGTTGAAGATGGCG
AAGCAGTGCCGGAAGGAACCAACGTTGAAAACTGGCTATCTGATCCAGATTACGCCGGCGTCGTCTGGGCGCTCGTCGAT
GTGGATATCACTCGGCTTATGGGCAAGGCGGAGAAAATTAACGTGACACTCCCTTCCCTGCTGATCCGCCGTATCGACCA
GTTTGTCGCCGCGCATCCTGAGTACGGTAGCCGTTCTGGCTTCCTCTCACGGGTTGCAGCTGATAGAGTGATAAGCAGGG
AAAATCGTTAA

Structures

Toxin

• AlphaFold DB: A0A0Z9JWN4