Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Xre-MNT/HTH_26(antitoxin) |
| Location | 957960..959068 | Replicon | chromosome |
| Accession | NZ_CP091422 | ||
| Organism | Streptococcus suis strain LSM157 | ||
Toxin (Protein)
| Gene name | MNTss | Uniprot ID | R3JIN1 |
| Locus tag | L3X06_RS04705 | Protein ID | WP_000233000.1 |
| Coordinates | 957960..958829 (-) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | Xress | Uniprot ID | - |
| Locus tag | L3X06_RS04710 | Protein ID | WP_000205227.1 |
| Coordinates | 958844..959068 (-) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L3X06_RS04675 (L3X06_04675) | 952974..953234 | + | 261 | Protein_875 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
| L3X06_RS04680 (L3X06_04680) | 953276..953650 | + | 375 | WP_001140406.1 | TnpV protein | - |
| L3X06_RS04685 (L3X06_04685) | 954017..955936 | + | 1920 | WP_012775603.1 | tetracycline resistance ribosomal protection protein Tet(O) | - |
| L3X06_RS04690 (L3X06_04690) | 955988..956176 | + | 189 | WP_079394308.1 | cysteine-rich KTR domain-containing protein | - |
| L3X06_RS04695 (L3X06_04695) | 956349..957212 | - | 864 | WP_002294505.1 | aminoglycoside nucleotidyltransferase ANT(6)-Ia | - |
| L3X06_RS04700 (L3X06_04700) | 957245..957979 | - | 735 | WP_000662263.1 | class I SAM-dependent methyltransferase | - |
| L3X06_RS04705 (L3X06_04705) | 957960..958829 | - | 870 | WP_000233000.1 | nucleotidyltransferase domain-containing protein | Toxin |
| L3X06_RS04710 (L3X06_04710) | 958844..959068 | - | 225 | WP_000205227.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| L3X06_RS04715 (L3X06_04715) | 959211..960755 | - | 1545 | WP_106474374.1 | recombinase family protein | - |
| L3X06_RS04720 (L3X06_04720) | 960775..961191 | - | 417 | WP_000323438.1 | recombinase | - |
| L3X06_RS04725 (L3X06_04725) | 961192..961689 | - | 498 | WP_002327635.1 | DNA recombinase | - |
| L3X06_RS04730 (L3X06_04730) | 962055..962888 | + | 834 | WP_225938940.1 | hypothetical protein | - |
| L3X06_RS04735 (L3X06_04735) | 963130..963984 | + | 855 | WP_225938941.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | erm(B) / tet(O) / ant(6)-Ia / tet(M) | - | 918939..1022244 | 103305 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 32926.57 Da Isoelectric Point: 4.8781
>T233286 WP_000233000.1 NZ_CP091422:c958829-957960 [Streptococcus suis]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
Download Length: 870 bp
>T233286 NZ_HG326223:c2652779-2652426 [Serratia marcescens subsp. marcescens Db11]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTACAGATCGCTCAGCGATGCCGATCGGGCCGGCGTACTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGTGCCGAGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAGCGTTTTTACGATCGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTACAGATCGCTCAGCGATGCCGATCGGGCCGGCGTACTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGTGCCGAGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAGCGTTTTTACGATCGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8365.68 Da Isoelectric Point: 4.5510
>AT233286 WP_000205227.1 NZ_CP091422:c959068-958844 [Streptococcus suis]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE
Download Length: 225 bp
>AT233286 NZ_HG326223:c2652421-2652119 [Serratia marcescens subsp. marcescens Db11]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATTGAACTGCCGGACGGTTCGCACTACGAATTTGTGCTGTAA
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATTGAACTGCCGGACGGTTCGCACTACGAATTTGTGCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|