Detailed information of TA system TA233286

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Xre-MNT/HTH_26(antitoxin)
• Location: 957960..959068
• Replicon: chromosome
• Accession: NZ_CP091422
• Organism: Streptococcus suis strain LSM157

Toxin (Protein)

• Gene name: MNTss
• Uniprot ID: R3JIN1
• Locus tag: L3X06_RS04705
• Protein ID: WP_000233000.1
• Coordinates: 957960..958829 (-)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: Xress
• Uniprot ID: -
• Locus tag: L3X06_RS04710
• Protein ID: WP_000205227.1
• Coordinates: 958844..959068 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L3X06_RS04675 (L3X06_04675)	952974..953234	+	261	Protein_875	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
L3X06_RS04680 (L3X06_04680)	953276..953650	+	375	WP_001140406.1	TnpV protein	-
L3X06_RS04685 (L3X06_04685)	954017..955936	+	1920	WP_012775603.1	tetracycline resistance ribosomal protection protein Tet(O)	-
L3X06_RS04690 (L3X06_04690)	955988..956176	+	189	WP_079394308.1	cysteine-rich KTR domain-containing protein	-
L3X06_RS04695 (L3X06_04695)	956349..957212	-	864	WP_002294505.1	aminoglycoside nucleotidyltransferase ANT(6)-Ia	-
L3X06_RS04700 (L3X06_04700)	957245..957979	-	735	WP_000662263.1	class I SAM-dependent methyltransferase	-
L3X06_RS04705 (L3X06_04705)	957960..958829	-	870	WP_000233000.1	nucleotidyltransferase domain-containing protein	Toxin
L3X06_RS04710 (L3X06_04710)	958844..959068	-	225	WP_000205227.1	helix-turn-helix transcriptional regulator	Antitoxin
L3X06_RS04715 (L3X06_04715)	959211..960755	-	1545	WP_106474374.1	recombinase family protein	-
L3X06_RS04720 (L3X06_04720)	960775..961191	-	417	WP_000323438.1	recombinase	-
L3X06_RS04725 (L3X06_04725)	961192..961689	-	498	WP_002327635.1	DNA recombinase	-
L3X06_RS04730 (L3X06_04730)	962055..962888	+	834	WP_225938940.1	hypothetical protein	-
L3X06_RS04735 (L3X06_04735)	963130..963984	+	855	WP_225938941.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	erm(B) / tet(O) / ant(6)-Ia / tet(M)	-	918939..1022244	103305

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polymerase, nucleotidyl transferase domain (12-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-57)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 32926.57 Da
• Isoelectric Point: 4.8781

>T233286 WP_000233000.1 NZ_CP091422:c958829-957960 [Streptococcus suis]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Nucleotide

• Length: 870 bp

>T233286 NZ_HG326223:c2652779-2652426 [Serratia marcescens subsp. marcescens Db11]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTACAGATCGCTCAGCGATGCCGATCGGGCCGGCGTACTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGTGCCGAGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAGCGTTTTTACGATCGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8365.68 Da
• Isoelectric Point: 4.5510

>AT233286 WP_000205227.1 NZ_CP091422:c959068-958844 [Streptococcus suis]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Nucleotide

• Length: 225 bp

>AT233286 NZ_HG326223:c2652421-2652119 [Serratia marcescens subsp. marcescens Db11]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATTGAACTGCCGGACGGTTCGCACTACGAATTTGTGCTGTAA

Structures

Toxin

• AlphaFold DB: R3JIN1