Detailed information of TA system TA233285

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 940202..941634
• Replicon: chromosome
• Accession: NZ_CP091422
• Organism: Streptococcus suis strain LSM157

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: A0A0H3MV40
• Locus tag: L3X06_RS04635
• Protein ID: WP_012775600.1
• Coordinates: 940202..941047 (-)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: A0A0H3MZG0
• Locus tag: L3X06_RS04640
• Protein ID: WP_012775601.1
• Coordinates: 941044..941634 (-)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L3X06_RS04630 (L3X06_04630)	937339..940140	+	2802	WP_012775599.1	phage tail tip lysozyme	-
L3X06_RS04635 (L3X06_04635)	940202..941047	-	846	WP_012775600.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
L3X06_RS04640 (L3X06_04640)	941044..941634	-	591	WP_012775601.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	erm(B) / tet(O) / ant(6)-Ia / tet(M)	-	918939..1022244	103305

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32444.16 Da
• Isoelectric Point: 5.2246

>T233285 WP_012775600.1 NZ_CP091422:c941047-940202 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIFSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFEKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLIAVLISINSD

Nucleotide

• Length: 846 bp

>T233285 NZ_HG326223:1278780-1278876 [Serratia marcescens subsp. marcescens Db11]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23189.70 Da
• Isoelectric Point: 7.3108

>AT233285 WP_012775601.1 NZ_CP091422:c941634-941044 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALNIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRAYDFERIICDLVIHREKIDTELFVKT
LQHYGNYPQKNLTKLYEYATKMNTLAKVKQTLEVLV

Nucleotide

• Length: 591 bp

>AT233285 NZ_HG326223:c1278876-1278736 [Serratia marcescens subsp. marcescens Db11]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Structures

Toxin

• AlphaFold DB: A0A0H3MV40

Antitoxin

• AlphaFold DB: A0A0H3MZG0