Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 472647..473284 | Replicon | chromosome |
Accession | NZ_CP091421 | ||
Organism | Bacillus sp. R45 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | G4NU33 |
Locus tag | L3V45_RS02420 | Protein ID | WP_003156187.1 |
Coordinates | 472934..473284 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | I2HMS5 |
Locus tag | L3V45_RS02415 | Protein ID | WP_003156188.1 |
Coordinates | 472647..472928 (+) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L3V45_RS02395 (L3V45_02395) | 469012..469611 | - | 600 | WP_003156193.1 | rhomboid family intramembrane serine protease | - |
L3V45_RS02400 (L3V45_02400) | 469704..470069 | + | 366 | WP_003156192.1 | holo-ACP synthase | - |
L3V45_RS02405 (L3V45_02405) | 470234..471241 | + | 1008 | WP_003156191.1 | outer membrane lipoprotein carrier protein LolA | - |
L3V45_RS02410 (L3V45_02410) | 471358..472527 | + | 1170 | WP_003156189.1 | alanine racemase | - |
L3V45_RS02415 (L3V45_02415) | 472647..472928 | + | 282 | WP_003156188.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
L3V45_RS02420 (L3V45_02420) | 472934..473284 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
L3V45_RS02425 (L3V45_02425) | 473402..474223 | + | 822 | WP_003156182.1 | STAS domain-containing protein | - |
L3V45_RS02430 (L3V45_02430) | 474228..474593 | + | 366 | WP_003156180.1 | RsbT antagonist protein RsbS | - |
L3V45_RS02435 (L3V45_02435) | 474596..474997 | + | 402 | WP_003156178.1 | anti-sigma regulatory factor | - |
L3V45_RS02440 (L3V45_02440) | 475009..476016 | + | 1008 | WP_025853725.1 | PP2C family protein-serine/threonine phosphatase | - |
L3V45_RS02445 (L3V45_02445) | 476080..476409 | + | 330 | WP_003156176.1 | anti-sigma factor antagonist RsbV | - |
L3V45_RS02450 (L3V45_02450) | 476406..476888 | + | 483 | WP_003156173.1 | anti-sigma B factor RsbW | - |
L3V45_RS02455 (L3V45_02455) | 476854..477642 | + | 789 | WP_003156171.1 | RNA polymerase sigma factor SigB | - |
L3V45_RS02460 (L3V45_02460) | 477642..478244 | + | 603 | WP_003156170.1 | PP2C family serine/threonine-protein phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T233283 WP_003156187.1 NZ_CP091421:472934-473284 [Bacillus sp. R45]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T233283 NZ_HG326223:c389198-388995 [Serratia marcescens subsp. marcescens Db11]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10562.92 Da Isoelectric Point: 6.4706
>AT233283 WP_003156188.1 NZ_CP091421:472647-472928 [Bacillus sp. R45]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT233283 NZ_HG326223:c389617-389249 [Serratia marcescens subsp. marcescens Db11]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGCTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GATGATACCTATACGCTGTTCAGCAGTTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAA
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGCTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GATGATACCTATACGCTGTTCAGCAGTTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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