Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1653015..1653492 Replicon chromosome
Accession NZ_CP091412
Organism Staphylococcus aureus strain ATR-20003

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag L3I92_RS08360 Protein ID WP_000052076.1
Coordinates 1653304..1653492 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag L3I92_RS08355 Protein ID WP_001059690.1
Coordinates 1653015..1653275 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3I92_RS08320 (1648408) 1648408..1649124 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
L3I92_RS08325 (1649272) 1649272..1649694 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
L3I92_RS08330 (1650093) 1650093..1650587 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
L3I92_RS08335 (1650743) 1650743..1651360 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
L3I92_RS08340 (1651433) 1651433..1652014 - 582 WP_001140696.1 histidine phosphatase family protein -
L3I92_RS08345 (1652238) 1652238..1652474 + 237 WP_000368687.1 hypothetical protein -
L3I92_RS08350 (1652471) 1652471..1652674 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
L3I92_RS08355 (1653015) 1653015..1653275 + 261 WP_001059690.1 hypothetical protein Antitoxin
L3I92_RS08360 (1653304) 1653304..1653492 + 189 WP_000052076.1 hypothetical protein Toxin
L3I92_RS08365 (1653680) 1653680..1654249 + 570 WP_001106662.1 lipoprotein N-acylation protein LnsA -
L3I92_RS08370 (1654337) 1654337..1654609 + 273 WP_001004400.1 hypothetical protein -
L3I92_RS08375 (1654682) 1654682..1654900 + 219 WP_000005875.1 hypothetical protein -
L3I92_RS08380 (1655397) 1655397..1655597 - 201 WP_001059082.1 cold-shock protein -
L3I92_RS08385 (1655954) 1655954..1656640 - 687 WP_001622483.1 thermonuclease family protein -
L3I92_RS08390 (1656981) 1656981..1657502 - 522 WP_000824479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(14-94)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T233282 WP_000052076.1 NZ_CP091412:1653304-1653492 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T233282 NZ_HG322950:c5843844-5843530 [Pseudomonas knackmussii B13]
ATGACCTCAAGGACTGGTGACGCAGAGAAGCACTACGAGCTCCGATTCAAGGCCTCGGCCAAGAAAGAATGGGACAAGCT
CATTGGTCCCGTGAAACAACAGCTACATGCCAAGCTGGCCGAGCGGCTGAAGAACCCGCGGGTGGAGTCGGCCAAGCTAC
ACGGCCAGGACCAGAAGGACCGCTACAAGATCAAATTGCGGTCATCTGGTTATCGGCTGGTCTATCAGGTCTACGACGAC
ATCGTGGTCGTTGAGGTCATCGCGGTAGGCAAGCGCGAACGCGGCAGCGTCTACGAGAACGCTCGGAAGCGCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT233282 WP_001059690.1 NZ_CP091412:1653015-1653275 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT233282 NZ_HG322950:c5844082-5843825 [Pseudomonas knackmussii B13]
ATGGCACACGCTATGTTGGCTGACGTTGCGGCCTCCATCACTGAGCTGAAGAAAGACCCCATGGGGACGGTAGGGGCCGG
TATGGGCCACGCTGTTGCGATCCTCAACCGCAATGAGCCGGTGTTCTATGTCGTTCCTGCGGATGAGTACGAGCGGATGG
TCGAGTTGCTTGACGACATCTACCTGGGGCGCCTCGCAGATGAGCGTGCGGATGAATCGACGGTGACGGTAACCCTGGAT
GACCTCAAGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References