Detailed information of TA system TA233275

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 411705..412219
• Replicon: chromosome
• Accession: NZ_CP091412
• Organism: Staphylococcus aureus strain ATR-20003

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: A0A0U1MQX5
• Locus tag: L3I92_RS02105
• Protein ID: WP_000581795.1
• Coordinates: 412010..412219 (+)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: L3I92_RS02100
• Protein ID: WP_237269216.1
• Coordinates: 411705..411998 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L3I92_RS02080 (407230)	407230..407871	+	642	WP_000483162.1	thiamine phosphate synthase	-
L3I92_RS02085 (407957)	407957..408829	+	873	WP_000725802.1	membrane protein insertase YidC	-
L3I92_RS02090 (409379)	409379..410027	-	649	Protein_408	HD domain-containing protein	-
L3I92_RS02095 (410055)	410055..411539	-	1485	WP_000571562.1	cardiolipin synthase	-
L3I92_RS02100 (411705)	411705..411998	+	294	WP_237269216.1	copper-sensing transcriptional repressor CsoR	Antitoxin
L3I92_RS02105 (412010)	412010..412219	+	210	WP_000581795.1	heavy metal-associated domain-containing protein	Toxin
L3I92_RS02110 (412347)	412347..412484	+	138	WP_000828354.1	Lmo0850 family protein	-
L3I92_RS02115 (412748)	412748..413950	-	1203	WP_001109939.1	FtsW/RodA/SpoVE family cell cycle protein	-
L3I92_RS02120 (414268)	414268..415338	+	1071	WP_000159637.1	D-alanine--D-alanine ligase	-
L3I92_RS02125 (415353)	415353..416711	+	1359	WP_000611479.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7842.83 Da
• Isoelectric Point: 4.3869

>T233275 WP_000581795.1 NZ_CP091412:412010-412219 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T233275 NZ_HG322949:5920718-5920900 [Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628]
ATGAACAGCGCAGACATAATCAAACAACTAAAGTCCGATGGCTGGGAACACGTCTCCACTCGTGGCAGCCATCACAAATA
CCGCAACCCTAAAACTGGCAAGTCTGTGATCGTTCCGCACCCGAAAAAAGACCTGCCGATAGGCACGGTCAATTCGATCC
TGAAACAAGCTCAATTAAAGTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11170.75 Da
• Isoelectric Point: 5.1715

>AT233275 WP_237269216.1 NZ_CP091412:411705-411998 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIED

Nucleotide

• Length: 294 bp

>AT233275 NZ_HG322949:5920909-5921292 [Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628]
ATGTTGTATCCACTCTACGTATGGAAAGACGCCAACAGCGCCTATGGCGCTTCCTTTCCCGACCTGCCTGGCGTCAATAC
CGCCGCCGATGAACTGCACGATCTCAGCAAGGCCGCTCAAGAAGCTGTTGAGGTGATGTATGACCGAGAAACGAATATTC
CAGCAGCTTCCGCCATCGAGAAATGGACAAGCAATCCGGACTATGCCGATGGTTTCTGGATGCTGGTTAATATCGACCTA
TCGAAAGTCAACACCAAGCCGGTTCGGCTGAACATCTCCTTGCCGGAAAGCCTGCTGCGAGATATCGATCAGTTCGCAAA
ATCACACCACCTCACGCGCTCAGGCTTCTTAGCTCAGGCGGCGATGAGAGCAATGGCGGAATAA

Structures

Toxin

• AlphaFold DB: A0A0U1MQX5