Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3699699..3700420 Replicon chromosome
Accession NZ_CP091381
Organism Amycolatopsis sp. FU40

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L3Q65_RS17850 Protein ID WP_237600300.1
Coordinates 3699699..3700151 (-) Length 151 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L3Q65_RS17855 Protein ID WP_182895284.1
Coordinates 3700148..3700420 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3Q65_RS17835 (L3Q65_17835) 3694990..3697857 + 2868 WP_237600299.1 alpha/beta fold hydrolase -
L3Q65_RS17840 (L3Q65_17840) 3697854..3698792 + 939 WP_182895281.1 ABC transporter permease subunit -
L3Q65_RS17845 (L3Q65_17845) 3698819..3699574 + 756 WP_182895282.1 enoyl-CoA hydratase/isomerase family protein -
L3Q65_RS17850 (L3Q65_17850) 3699699..3700151 - 453 WP_237600300.1 type II toxin-antitoxin system VapC family toxin Toxin
L3Q65_RS17855 (L3Q65_17855) 3700148..3700420 - 273 WP_182895284.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L3Q65_RS17860 (L3Q65_17860) 3700449..3702548 - 2100 WP_182895390.1 excinuclease ABC subunit UvrB -
L3Q65_RS17865 (L3Q65_17865) 3702839..3704206 - 1368 WP_237600301.1 DUF5685 family protein -
L3Q65_RS17870 (L3Q65_17870) 3704321..3704839 + 519 WP_182895286.1 DUF402 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-119)

Antitoxin

Antitoxin VapB-like

(1-86)


Sequences

Toxin        


Download         Length: 151 a.a.        Molecular weight: 16267.62 Da        Isoelectric Point: 6.7004

>T233268 WP_237600300.1 NZ_CP091381:c3700151-3699699 [Amycolatopsis sp. FU40]
VIIDSSAVVAVLLGEPLAVPIARAIGGAEECRIGAPTLAETSIVLTHKEGERGATLLASFLQRRRFDILTFGEAHWRTAQ
TAYLRYGKGRHPAALNFGDCLTYAAAKLAGEPLLCIGDDFPQTDLELVKLERTDRIRDNERPPTRGCAPN

Download         Length: 453 bp

>T233268 NZ_HF572917:5079463-5079813 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9984.21 Da        Isoelectric Point: 4.6820

>AT233268 WP_182895284.1 NZ_CP091381:c3700420-3700148 [Amycolatopsis sp. FU40]
MALNIKDPETERLAAEVAELTGTTKTGAVRDSLRIMRDRLLAQRSAEQNADDFVRFLQDEIWPQVSAENRGKPVSKAERE
EILGYGPGGV

Download         Length: 273 bp

>AT233268 NZ_HF572917:5079218-5079469 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References