Detailed information of TA system TA233266

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1367328..1367981
• Replicon: chromosome
• Accession: NZ_CP091378
• Organism: Acinetobacter baumannii strain AB3-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z04_RS06725
• Protein ID: WP_000607077.1
• Coordinates: 1367592..1367981 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z04_RS06720
• Protein ID: WP_001288210.1
• Coordinates: 1367328..1367585 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z04_RS06700 (L2Z04_06700)	1362844..1363851	+	1008	WP_000198633.1	DNA-directed RNA polymerase subunit alpha	-
L2Z04_RS06705 (L2Z04_06705)	1363870..1364247	+	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z04_RS06710 (L2Z04_06710)	1364429..1365919	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z04_RS06715 (L2Z04_06715)	1365968..1367140	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
L2Z04_RS06720 (L2Z04_06720)	1367328..1367585	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z04_RS06725 (L2Z04_06725)	1367592..1367981	+	390	WP_000607077.1	membrane protein	Toxin
L2Z04_RS06730 (L2Z04_06730)	1368751..1369836	+	1086	WP_000049106.1	hypothetical protein	-
L2Z04_RS06735 (L2Z04_06735)	1369914..1370480	+	567	WP_000651538.1	rhombosortase	-
L2Z04_RS06740 (L2Z04_06740)	1370668..1372863	+	2196	WP_001158909.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233266 WP_000607077.1 NZ_CP091378:1367592-1367981 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233266 NZ_HF572917:4933352-4933525 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233266 WP_001288210.1 NZ_CP091378:1367328-1367585 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233266 NZ_HF572917:4933028-4933324 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7