233265

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 898327..898980 Replicon chromosome
Accession NZ_CP091377
Organism Acinetobacter baumannii strain AB9-VUB

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag L2Z15_RS04140 Protein ID WP_000931890.1
Coordinates 898327..898716 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag L2Z15_RS04145 Protein ID WP_001288210.1
Coordinates 898723..898980 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z15_RS04125 (L2Z15_04120) 893445..895640 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
L2Z15_RS04130 (L2Z15_04125) 895828..896394 - 567 WP_000651536.1 rhombosortase -
L2Z15_RS04135 (L2Z15_04130) 896472..897557 - 1086 WP_000049106.1 hypothetical protein -
L2Z15_RS04140 (L2Z15_04135) 898327..898716 - 390 WP_000931890.1 membrane protein Toxin
L2Z15_RS04145 (L2Z15_04140) 898723..898980 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
L2Z15_RS04150 (L2Z15_04145) 899168..900340 + 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
L2Z15_RS04155 (L2Z15_04150) 900390..901880 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
L2Z15_RS04160 (L2Z15_04155) 902060..902437 - 378 WP_001216380.1 50S ribosomal protein L17 -
L2Z15_RS04165 (L2Z15_04160) 902456..903463 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T233265 WP_000931890.1 NZ_CP091377:c898716-898327 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T233265 NZ_HF572917:4656258-4656569 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT233265 WP_001288210.1 NZ_CP091377:c898980-898723 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT233265 NZ_HF572917:4656570-4656860 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTCAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References