Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3217451..3218104 Replicon chromosome
Accession NZ_CP091376
Organism Acinetobacter baumannii strain AB14-VUB

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag L2Z26_RS15360 Protein ID WP_000931890.1
Coordinates 3217715..3218104 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag L2Z26_RS15355 Protein ID WP_001288210.1
Coordinates 3217451..3217708 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z26_RS15335 (L2Z26_15330) 3212967..3213974 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
L2Z26_RS15340 (L2Z26_15335) 3213993..3214370 + 378 WP_001216380.1 50S ribosomal protein L17 -
L2Z26_RS15345 (L2Z26_15340) 3214551..3216041 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
L2Z26_RS15350 (L2Z26_15345) 3216091..3217263 - 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
L2Z26_RS15355 (L2Z26_15350) 3217451..3217708 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
L2Z26_RS15360 (L2Z26_15355) 3217715..3218104 + 390 WP_000931890.1 membrane protein Toxin
L2Z26_RS15365 (L2Z26_15360) 3218874..3219959 + 1086 WP_000049106.1 hypothetical protein -
L2Z26_RS15370 (L2Z26_15365) 3220037..3220603 + 567 WP_000651536.1 rhombosortase -
L2Z26_RS15375 (L2Z26_15370) 3220791..3222986 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T233264 WP_000931890.1 NZ_CP091376:3217715-3218104 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T233264 NZ_HF572917:4405411-4405788 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT233264 WP_001288210.1 NZ_CP091376:3217451-3217708 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT233264 NZ_HF572917:4404987-4405364 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References