Detailed information of TA system TA233262

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2409954..2410607
• Replicon: chromosome
• Accession: NZ_CP091375
• Organism: Acinetobacter baumannii strain AB16-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z37_RS11880
• Protein ID: WP_000607077.1
• Coordinates: 2410218..2410607 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z37_RS11875
• Protein ID: WP_001288210.1
• Coordinates: 2409954..2410211 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z37_RS11855 (L2Z37_11855)	2405470..2406477	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
L2Z37_RS11860 (L2Z37_11860)	2406496..2406873	+	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z37_RS11865 (L2Z37_11865)	2407055..2408545	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z37_RS11870 (L2Z37_11870)	2408594..2409766	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
L2Z37_RS11875 (L2Z37_11875)	2409954..2410211	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z37_RS11880 (L2Z37_11880)	2410218..2410607	+	390	WP_000607077.1	membrane protein	Toxin
L2Z37_RS11885 (L2Z37_11885)	2411377..2412462	+	1086	WP_000049106.1	hypothetical protein	-
L2Z37_RS11890 (L2Z37_11890)	2412540..2413106	+	567	WP_000651538.1	rhombosortase	-
L2Z37_RS11895 (L2Z37_11895)	2413294..2415489	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233262 WP_000607077.1 NZ_CP091375:2410218-2410607 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233262 NZ_HF572917:3594172-3594549 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233262 WP_001288210.1 NZ_CP091375:2409954-2410211 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233262 NZ_HF572917:3593748-3594125 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCATGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7