Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3915362..3916015 Replicon chromosome
Accession NZ_CP091374
Organism Acinetobacter baumannii strain AB20-VUB

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag L2Z45_RS18635 Protein ID WP_000931890.1
Coordinates 3915626..3916015 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag L2Z45_RS18630 Protein ID WP_001288210.1
Coordinates 3915362..3915619 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z45_RS18610 (L2Z45_18600) 3910878..3911885 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
L2Z45_RS18615 (L2Z45_18605) 3911904..3912281 + 378 WP_001216380.1 50S ribosomal protein L17 -
L2Z45_RS18620 (L2Z45_18610) 3912462..3913952 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
L2Z45_RS18625 (L2Z45_18615) 3914002..3915174 - 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
L2Z45_RS18630 (L2Z45_18620) 3915362..3915619 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
L2Z45_RS18635 (L2Z45_18625) 3915626..3916015 + 390 WP_000931890.1 membrane protein Toxin
L2Z45_RS18640 (L2Z45_18630) 3916785..3917870 + 1086 WP_000049106.1 hypothetical protein -
L2Z45_RS18645 (L2Z45_18635) 3917948..3918514 + 567 WP_000651536.1 rhombosortase -
L2Z45_RS18650 (L2Z45_18640) 3918702..3920897 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T233261 WP_000931890.1 NZ_CP091374:3915626-3916015 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T233261 NZ_HF572917:c3433790-3433383 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT233261 WP_001288210.1 NZ_CP091374:3915362-3915619 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT233261 NZ_HF572917:c3434037-3433771 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References