Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/-
Location 2323699..2324352 Replicon chromosome
Accession NZ_CP091373
Organism Acinetobacter baumannii strain AB21-VUB

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag L2Z46_RS11190 Protein ID WP_000607070.1
Coordinates 2323699..2324088 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag L2Z46_RS11195 Protein ID WP_001288210.1
Coordinates 2324095..2324352 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z46_RS11175 (L2Z46_11175) 2318817..2321012 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
L2Z46_RS11180 (L2Z46_11180) 2321200..2321766 - 567 WP_000651536.1 rhombosortase -
L2Z46_RS11185 (L2Z46_11185) 2321844..2322929 - 1086 WP_000049107.1 hypothetical protein -
L2Z46_RS11190 (L2Z46_11190) 2323699..2324088 - 390 WP_000607070.1 hypothetical protein Toxin
L2Z46_RS11195 (L2Z46_11195) 2324095..2324352 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
L2Z46_RS11200 (L2Z46_11200) 2324540..2325712 + 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
L2Z46_RS11205 (L2Z46_11205) 2325762..2327252 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
L2Z46_RS11210 (L2Z46_11210) 2327433..2327810 - 378 WP_001216380.1 50S ribosomal protein L17 -
L2Z46_RS11215 (L2Z46_11215) 2327829..2328836 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(10-82)


Sequences


Toxin        


Download         Length: 130 a.a.        Molecular weight: 15708.02 Da        Isoelectric Point: 10.3599

>T233260 WP_000607070.1 NZ_CP091373:c2324088-2323699 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEDHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T233260 NZ_HF572917:c3297531-3297196 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT233260 WP_001288210.1 NZ_CP091373:c2324352-2324095 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT233260 NZ_HF572917:c3297779-3297531 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References