Detailed information of TA system TA233259

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1105651..1106304
• Replicon: chromosome
• Accession: NZ_CP091372
• Organism: Acinetobacter baumannii strain AB32-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z47_RS05290
• Protein ID: WP_002068666.1
• Coordinates: 1105651..1106040 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z47_RS05295
• Protein ID: WP_001288210.1
• Coordinates: 1106047..1106304 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z47_RS05275 (L2Z47_05255)	1100769..1102964	-	2196	WP_001158905.1	TRAP transporter large permease subunit	-
L2Z47_RS05280 (L2Z47_05260)	1103152..1103718	-	567	WP_000651536.1	rhombosortase	-
L2Z47_RS05285 (L2Z47_05265)	1103796..1104881	-	1086	WP_000049107.1	hypothetical protein	-
L2Z47_RS05290 (L2Z47_05270)	1105651..1106040	-	390	WP_002068666.1	hypothetical protein	Toxin
L2Z47_RS05295 (L2Z47_05275)	1106047..1106304	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z47_RS05300 (L2Z47_05280)	1106492..1107664	+	1173	WP_001190549.1	acyl-CoA dehydrogenase family protein	-
L2Z47_RS05305 (L2Z47_05285)	1107713..1109203	-	1491	WP_000415133.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z47_RS05310 (L2Z47_05290)	1109385..1109762	-	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z47_RS05315 (L2Z47_05295)	1109781..1110788	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15673.92 Da
• Isoelectric Point: 10.4637

>T233259 WP_002068666.1 NZ_CP091372:c1106040-1105651 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLTQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKFH

Nucleotide

• Length: 390 bp

>T233259 NZ_HF572917:c2989572-2989174 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233259 WP_001288210.1 NZ_CP091372:c1106304-1106047 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233259 NZ_HF572917:c2989799-2989572 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7