Detailed information of TA system TA233258

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3289435..3290088
• Replicon: chromosome
• Accession: NZ_CP091371
• Organism: Acinetobacter baumannii strain AB36-VUB

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2Z48_RS15870
• Protein ID: WP_000607077.1
• Coordinates: 3289435..3289824 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: L2Z48_RS15875
• Protein ID: WP_001288210.1
• Coordinates: 3289831..3290088 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z48_RS15855 (L2Z48_15850)	3284553..3286748	-	2196	Protein_3102	TRAP transporter large permease subunit	-
L2Z48_RS15860 (L2Z48_15855)	3286936..3287502	-	567	WP_000651538.1	rhombosortase	-
L2Z48_RS15865 (L2Z48_15860)	3287580..3288665	-	1086	WP_000049106.1	hypothetical protein	-
L2Z48_RS15870 (L2Z48_15865)	3289435..3289824	-	390	WP_000607077.1	membrane protein	Toxin
L2Z48_RS15875 (L2Z48_15870)	3289831..3290088	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
L2Z48_RS15880 (L2Z48_15875)	3290276..3291448	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
L2Z48_RS15885 (L2Z48_15880)	3291497..3292987	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
L2Z48_RS15890 (L2Z48_15885)	3293167..3293544	-	378	WP_001216380.1	50S ribosomal protein L17	-
L2Z48_RS15895 (L2Z48_15890)	3293563..3294570	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T233258 WP_000607077.1 NZ_CP091371:c3289824-3289435 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T233258 NZ_HF572917:c2485727-2485476 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT233258 WP_001288210.1 NZ_CP091371:c3290088-3289831 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT233258 NZ_HF572917:c2485479-2485225 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7