Detailed information of TA system TA233257

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2664716..2665367
• Replicon: chromosome
• Accession: NZ_CP091371
• Organism: Acinetobacter baumannii strain AB36-VUB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: L2Z48_RS12740
• Protein ID: WP_000838146.1
• Coordinates: 2665185..2665367 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0J1AAF8
• Locus tag: L2Z48_RS12735
• Protein ID: WP_000966689.1
• Coordinates: 2664716..2665120 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z48_RS12720 (L2Z48_12715)	2659749..2660090	-	342	WP_001281459.1	phage tail protein	-
L2Z48_RS12725 (L2Z48_12720)	2660208..2664173	-	3966	WP_000191304.1	tape measure protein	-
L2Z48_RS12730 (L2Z48_12725)	2664234..2664635	-	402	WP_000720591.1	hypothetical protein	-
L2Z48_RS12735 (L2Z48_12730)	2664716..2665120	-	405	WP_000966689.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L2Z48_RS12740 (L2Z48_12735)	2665185..2665367	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
L2Z48_RS12745 (L2Z48_12740)	2665699..2666232	-	534	WP_001185622.1	hypothetical protein	-
L2Z48_RS12750 (L2Z48_12745)	2666277..2667206	-	930	WP_000094300.1	phage tail tube protein	-
L2Z48_RS12755 (L2Z48_12750)	2667314..2667526	-	213	WP_000121166.1	hypothetical protein	-
L2Z48_RS12760 (L2Z48_12755)	2667528..2667926	-	399	WP_001132270.1	hypothetical protein	-
L2Z48_RS12765 (L2Z48_12760)	2667928..2668296	-	369	WP_000539752.1	hypothetical protein	-
L2Z48_RS12770 (L2Z48_12765)	2668268..2668672	-	405	WP_000248324.1	hypothetical protein	-
L2Z48_RS12775 (L2Z48_12770)	2668681..2669049	-	369	WP_000524231.1	hypothetical protein	-
L2Z48_RS12780 (L2Z48_12775)	2669051..2669440	-	390	WP_000008492.1	hypothetical protein	-
L2Z48_RS12785 (L2Z48_12780)	2669445..2670110	-	666	WP_000767881.1	Ish1 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2645722..2689876	44154

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T233257 WP_000838146.1 NZ_CP091371:c2665367-2665185 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T233257 NZ_HF572917:c2485479-2485225 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14769.78 Da
• Isoelectric Point: 4.5000

>AT233257 WP_000966689.1 NZ_CP091371:c2665120-2664716 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT233257 NZ_HF572917:c2485727-2485476 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: A0A0J1AAF8