Detailed information of TA system TA233256

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 908273..908952
• Replicon: chromosome
• Accession: NZ_CP091370
• Organism: Acinetobacter baumannii strain AB39-VUB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: L2Z49_RS04325
• Protein ID: WP_000838146.1
• Coordinates: 908273..908455 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: L2Z49_RS04330
• Protein ID: WP_000966688.1
• Coordinates: 908548..908952 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z49_RS04290 (L2Z49_04290)	903470..903874	+	405	WP_000247946.1	hypothetical protein	-
L2Z49_RS04295 (L2Z49_04295)	903846..904214	+	369	WP_025464509.1	HK97 gp10 family phage protein	-
L2Z49_RS04300 (L2Z49_04300)	904216..904614	+	399	WP_001251854.1	phage tail terminator-like protein	-
L2Z49_RS04305 (L2Z49_04305)	904683..905036	+	354	WP_000064601.1	hypothetical protein	-
L2Z49_RS04310 (L2Z49_04310)	905036..906391	+	1356	WP_000002417.1	hypothetical protein	-
L2Z49_RS04315 (L2Z49_04315)	906444..907361	+	918	WP_000094247.1	phage tail tube protein	-
L2Z49_RS04320 (L2Z49_04320)	907432..907947	+	516	WP_025464510.1	hypothetical protein	-
L2Z49_RS04325 (L2Z49_04325)	908273..908455	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
L2Z49_RS04330 (L2Z49_04330)	908548..908952	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L2Z49_RS04335 (L2Z49_04335)	909052..909576	+	525	WP_000721574.1	DUF4468 domain-containing protein	-
L2Z49_RS04340 (L2Z49_04340)	909641..910024	+	384	WP_000725052.1	hypothetical protein	-
L2Z49_RS04345 (L2Z49_04345)	910086..910832	+	747	WP_000599537.1	hypothetical protein	-
L2Z49_RS04350 (L2Z49_04350)	910918..911409	+	492	WP_000755583.1	DUF4468 domain-containing protein	-
L2Z49_RS04355 (L2Z49_04355)	911452..911718	-	267	WP_000774879.1	hypothetical protein	-
L2Z49_RS04360 (L2Z49_04360)	911868..912803	+	936	WP_000254125.1	ORF6N domain-containing protein	-
L2Z49_RS04365 (L2Z49_04365)	913144..913659	+	516	WP_001056868.1	Rha family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	862977..942575	79598

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T233256 WP_000838146.1 NZ_CP091370:908273-908455 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T233256 NZ_HF572917:c2225457-2225354 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT233256 WP_000966688.1 NZ_CP091370:908548-908952 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT233256 NZ_HF572917:2225316-2225587 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6