Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3978612..3979265 Replicon chromosome
Accession NZ_CP091369
Organism Acinetobacter baumannii strain AB40-VUB

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag L2Z05_RS19115 Protein ID WP_000607070.1
Coordinates 3978876..3979265 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag L2Z05_RS19110 Protein ID WP_001288210.1
Coordinates 3978612..3978869 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z05_RS19090 (L2Z05_19090) 3974131..3975138 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
L2Z05_RS19095 (L2Z05_19095) 3975157..3975534 + 378 WP_001216380.1 50S ribosomal protein L17 -
L2Z05_RS19100 (L2Z05_19100) 3975713..3977203 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
L2Z05_RS19105 (L2Z05_19105) 3977252..3978424 - 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
L2Z05_RS19110 (L2Z05_19110) 3978612..3978869 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
L2Z05_RS19115 (L2Z05_19115) 3978876..3979265 + 390 WP_000607070.1 hypothetical protein Toxin
L2Z05_RS19120 (L2Z05_19120) 3980035..3981120 + 1086 WP_000049107.1 hypothetical protein -
L2Z05_RS19125 (L2Z05_19125) 3981198..3981764 + 567 WP_000651536.1 rhombosortase -
L2Z05_RS19130 (L2Z05_19130) 3981952..3984147 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15708.02 Da        Isoelectric Point: 10.3599

>T233254 WP_000607070.1 NZ_CP091369:3978876-3979265 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEDHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T233254 NZ_HF572917:c1467936-1467829 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT233254 WP_001288210.1 NZ_CP091369:3978612-3978869 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT233254 NZ_HF572917:1467983-1468049 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References