Detailed information of TA system TA233253

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3597452..3599078
• Replicon: chromosome
• Accession: NZ_CP091369
• Organism: Acinetobacter baumannii strain AB40-VUB

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: C1IUI3
• Locus tag: L2Z05_RS17185
• Protein ID: WP_000088044.1
• Coordinates: 3597753..3599078 (+)
• Length: 442 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: C1IUI2
• Locus tag: L2Z05_RS17180
• Protein ID: WP_000609339.1
• Coordinates: 3597452..3597748 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z05_RS17155 (L2Z05_17160)	3592772..3593227	+	456	WP_001166628.1	Hg(II)-responsive transcriptional regulator	-
L2Z05_RS17160 (L2Z05_17165)	3593284..3593646	+	363	WP_139937413.1	hypothetical protein	-
L2Z05_RS17165 (L2Z05_17170)	3594305..3594961	+	657	WP_000462754.1	trypsin-like serine protease	-
L2Z05_RS17170 (L2Z05_17175)	3595164..3595661	+	498	WP_000340139.1	membrane protein	-
L2Z05_RS17175 (L2Z05_17180)	3595666..3597054	+	1389	WP_000083579.1	hypothetical protein	-
L2Z05_RS17180 (L2Z05_17185)	3597452..3597748	+	297	WP_000609339.1	helix-turn-helix transcriptional regulator	Antitoxin
L2Z05_RS17185 (L2Z05_17190)	3597753..3599078	+	1326	WP_000088044.1	type II toxin-antitoxin system HipA family toxin	Toxin
L2Z05_RS17190 (L2Z05_17195)	3599139..3599345	+	207	WP_000134171.1	hypothetical protein	-
L2Z05_RS17195 (L2Z05_17200)	3599446..3599856	+	411	WP_000985909.1	hypothetical protein	-
L2Z05_RS17200 (L2Z05_17205)	3599869..3600684	+	816	WP_001641519.1	HNH endonuclease signature motif containing protein	-
L2Z05_RS17205 (L2Z05_17210)	3600958..3601362	+	405	WP_227551936.1	hypothetical protein	-
L2Z05_RS17210 (L2Z05_17215)	3602004..3602219	+	216	WP_227552088.1	hypothetical protein	-
L2Z05_RS17215 (L2Z05_17220)	3602235..3602720	+	486	WP_200451583.1	hypothetical protein	-
L2Z05_RS17220 (L2Z05_17225)	3602806..3603510	+	705	WP_001067858.1	IS6-like element IS26 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	mph(E) / msr(E) / armA / sul1 / qacE / aadA5 / aac(6')-Ian / floR / sul2	-	3562474..3626592	64118
	-	flank	IS/Tn	-	-	3602806..3603510	704

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (21-71)

Sequences

Toxin

Protein

• Length: 442 a.a.
• Molecular weight: 50333.32 Da
• Isoelectric Point: 6.5044

>T233253 WP_000088044.1 NZ_CP091369:3597753-3599078 [Acinetobacter baumannii]
MSRKQQRLAIWMNGIKVGYWEKSKGVDSLQYLPDWSADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMRSSVENEWLCSVLLEQYGLPVARTQIAHFEDQKALVVERF
DRKWSGNGQWIIRLPQEDMCQALGISPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIVFWMMAATDGHAKNFS
ISIGPQGRYHLTPLYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Nucleotide

• Length: 1326 bp

>T233253 NZ_HF572917:c1467400-1467293 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10991.49 Da
• Isoelectric Point: 10.3134

>AT233253 WP_000609339.1 NZ_CP091369:3597452-3597748 [Acinetobacter baumannii]
MINNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSTTASSEG
KQTEEMLKSNSPARQEKW

Nucleotide

• Length: 297 bp

>AT233253 NZ_HF572917:1467453-1467514 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A2S1XXW1

Antitoxin

• AlphaFold DB: A0A5S9LWW2